New Results
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients
Liqun He, Maarja Andaloussi Mäe, Ying Sun, Lars Muhl, Khayrun Nahar, Elisa Vázquez Liébanas, Malin Jonsson Fagerlund, Anders Oldner, Jianping Liu, Guillem Genové, Riikka Pietilä, Lei Zhang, Yuan Xie, Stefanos Leptidis, Guiseppe Mocci, Simon Stritt, Ahmed Osman, Andrey Anisimov, Karthik Amudhala Hemanthakumar, Markus Räsenen, Johan Björkegren, Michael Vanlandewijck, Klas Blomgren, Emil Hansson, Taija Mäkinen, Xiao-Rong Peng, Thomas D. Arnold, Kari Alitalo, Lars I Eriksson, Urban Lendahl, Christer Betsholtz
doi: https://doi.org/10.1101/2020.05.11.088500
Liqun He
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Maarja Andaloussi Mäe
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Ying Sun
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Lars Muhl
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
Khayrun Nahar
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Elisa Vázquez Liébanas
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Malin Jonsson Fagerlund
3Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Solna and Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
Anders Oldner
3Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Solna and Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
Jianping Liu
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
Guillem Genové
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
Riikka Pietilä
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Lei Zhang
4Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, China
Yuan Xie
4Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, China
Stefanos Leptidis
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
Guiseppe Mocci
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
Simon Stritt
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Ahmed Osman
5Department of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden
Andrey Anisimov
6Wihuri Research Institute and Translational Cancer Medicine Program, Biomedicum Helsinki, University of Helsinki, Finland
Karthik Amudhala Hemanthakumar
6Wihuri Research Institute and Translational Cancer Medicine Program, Biomedicum Helsinki, University of Helsinki, Finland
Markus Räsenen
6Wihuri Research Institute and Translational Cancer Medicine Program, Biomedicum Helsinki, University of Helsinki, Finland
Johan Björkegren
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
7Institute of Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, US
8Department of Pathophysiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
9Clinical Gene Networks AB, Stockholm, Sweden
Michael Vanlandewijck
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
Klas Blomgren
5Department of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden
10Cardiovascular, Renal and Metabolism (CVRM), IMED Biotech Unit, AstraZeneca BioPharmaceuticals R&D, Gothenburg, Sweden
Emil Hansson
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
Taija Mäkinen
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
Xiao-Rong Peng
11Department of Pediatric oncology, Karolinska University Hospital, Stockholm, Sweden
Thomas D. Arnold
12Department of Pediatrics, University of California San Francisco, USA
Kari Alitalo
6Wihuri Research Institute and Translational Cancer Medicine Program, Biomedicum Helsinki, University of Helsinki, Finland
Lars I Eriksson
3Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Solna and Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
Urban Lendahl
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
13Department of Cell and Molecular Biology, Karolinska Institutet, Sweden
Christer Betsholtz
1Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
2Integrated Cardio Metabolic Center (ICMC), Karolinska Institutet, Huddinge, Sweden
14Department of Medicine Huddinge, Karolinska Institutet, Sweden
- Supplemental Figures and Table[supplements/088500_file03.pdf]
Posted May 12, 2020.
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients
Liqun He, Maarja Andaloussi Mäe, Ying Sun, Lars Muhl, Khayrun Nahar, Elisa Vázquez Liébanas, Malin Jonsson Fagerlund, Anders Oldner, Jianping Liu, Guillem Genové, Riikka Pietilä, Lei Zhang, Yuan Xie, Stefanos Leptidis, Guiseppe Mocci, Simon Stritt, Ahmed Osman, Andrey Anisimov, Karthik Amudhala Hemanthakumar, Markus Räsenen, Johan Björkegren, Michael Vanlandewijck, Klas Blomgren, Emil Hansson, Taija Mäkinen, Xiao-Rong Peng, Thomas D. Arnold, Kari Alitalo, Lars I Eriksson, Urban Lendahl, Christer Betsholtz
bioRxiv 2020.05.11.088500; doi: https://doi.org/10.1101/2020.05.11.088500
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients
Liqun He, Maarja Andaloussi Mäe, Ying Sun, Lars Muhl, Khayrun Nahar, Elisa Vázquez Liébanas, Malin Jonsson Fagerlund, Anders Oldner, Jianping Liu, Guillem Genové, Riikka Pietilä, Lei Zhang, Yuan Xie, Stefanos Leptidis, Guiseppe Mocci, Simon Stritt, Ahmed Osman, Andrey Anisimov, Karthik Amudhala Hemanthakumar, Markus Räsenen, Johan Björkegren, Michael Vanlandewijck, Klas Blomgren, Emil Hansson, Taija Mäkinen, Xiao-Rong Peng, Thomas D. Arnold, Kari Alitalo, Lars I Eriksson, Urban Lendahl, Christer Betsholtz
bioRxiv 2020.05.11.088500; doi: https://doi.org/10.1101/2020.05.11.088500
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