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Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein
Seth J. Zost, Pavlo Gilchuk, Rita E. Chen, James Brett Case, Joseph X. Reidy, Andrew Trivette, Rachel S. Nargi, Rachel E. Sutton, Naveenchandra Suryadevara, Elaine C. Chen, Elad Binshtein, Swathi Shrihari, Mario Ostrowski, Helen Y. Chu, Jonathan E. Didier, Keith W. MacRenaris, Taylor Jones, Samuel Day, Luke Myers, F. Eun-Hyung Lee, Doan C. Nguyen, Ignacio Sanz, David R. Martinez, Ralph S. Baric, Larissa B. Thackray, Michael S. Diamond, View ORCID ProfileRobert H. Carnahan, James E. Crowe Jr.
doi: https://doi.org/10.1101/2020.05.12.091462
Seth J. Zost
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Pavlo Gilchuk
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Rita E. Chen
2Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA
9Department of Medicine, Washington University School of Medicine, St. Louis, 63110, MO, USA
James Brett Case
3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Joseph X. Reidy
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Andrew Trivette
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Rachel S. Nargi
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Rachel E. Sutton
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Naveenchandra Suryadevara
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Elaine C. Chen
3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Elad Binshtein
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Swathi Shrihari
9Department of Medicine, Washington University School of Medicine, St. Louis, 63110, MO, USA
Mario Ostrowski
4Department of Medicine, University of Toronto, Toronto, ON, Canada
Helen Y. Chu
5Division of Allergy and Infectious Diseases, University of Washington, Seattle 98109, USA
Jonathan E. Didier
6Berkeley Lights, Inc., Emeryville, CA, 94608, USA
Keith W. MacRenaris
6Berkeley Lights, Inc., Emeryville, CA, 94608, USA
Taylor Jones
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Samuel Day
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Luke Myers
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
F. Eun-Hyung Lee
7Department of Medicine, Emory University, Atlanta, GA, 30322 USA
Doan C. Nguyen
7Department of Medicine, Emory University, Atlanta, GA, 30322 USA
Ignacio Sanz
7Department of Medicine, Emory University, Atlanta, GA, 30322 USA
David R. Martinez
8Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
Ralph S. Baric
8Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA
Larissa B. Thackray
9Department of Medicine, Washington University School of Medicine, St. Louis, 63110, MO, USA
Michael S. Diamond
2Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA
9Department of Medicine, Washington University School of Medicine, St. Louis, 63110, MO, USA
10Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA
11Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, 63110, USA
Robert H. Carnahan
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
12Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
James E. Crowe Jr.
1Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
3Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
12Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA
Posted May 13, 2020.
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein
Seth J. Zost, Pavlo Gilchuk, Rita E. Chen, James Brett Case, Joseph X. Reidy, Andrew Trivette, Rachel S. Nargi, Rachel E. Sutton, Naveenchandra Suryadevara, Elaine C. Chen, Elad Binshtein, Swathi Shrihari, Mario Ostrowski, Helen Y. Chu, Jonathan E. Didier, Keith W. MacRenaris, Taylor Jones, Samuel Day, Luke Myers, F. Eun-Hyung Lee, Doan C. Nguyen, Ignacio Sanz, David R. Martinez, Ralph S. Baric, Larissa B. Thackray, Michael S. Diamond, Robert H. Carnahan, James E. Crowe Jr.
bioRxiv 2020.05.12.091462; doi: https://doi.org/10.1101/2020.05.12.091462
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein
Seth J. Zost, Pavlo Gilchuk, Rita E. Chen, James Brett Case, Joseph X. Reidy, Andrew Trivette, Rachel S. Nargi, Rachel E. Sutton, Naveenchandra Suryadevara, Elaine C. Chen, Elad Binshtein, Swathi Shrihari, Mario Ostrowski, Helen Y. Chu, Jonathan E. Didier, Keith W. MacRenaris, Taylor Jones, Samuel Day, Luke Myers, F. Eun-Hyung Lee, Doan C. Nguyen, Ignacio Sanz, David R. Martinez, Ralph S. Baric, Larissa B. Thackray, Michael S. Diamond, Robert H. Carnahan, James E. Crowe Jr.
bioRxiv 2020.05.12.091462; doi: https://doi.org/10.1101/2020.05.12.091462
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