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In Vitro Inhibition of SARS-CoV-2 Infection by Bovine Lactoferrin

View ORCID ProfileCarlos Alberto Marques de Carvalho, View ORCID ProfileAline da Rocha Matos, View ORCID ProfileBraulia Costa Caetano, View ORCID ProfileIvanildo Pedro de Sousa Junior, View ORCID ProfileSamir Pereira da Costa Campos, View ORCID ProfileBarbara Rodrigues Geraldino, View ORCID ProfileCaroline Augusto Barros, View ORCID ProfileMatheus Augusto Patricio de Almeida, View ORCID ProfileVanessa Pimenta Rocha, View ORCID ProfileAndréa Marques Vieira da Silva, View ORCID ProfileJuliana Gil Melgaço, View ORCID ProfilePatrícia Cristina da Costa Neves, View ORCID ProfileTamiris Azamor da Costa Barros, View ORCID ProfileAna Paula Dinis Ano Bom, View ORCID ProfileMarilda Mendonça Siqueira, Sotiris Missailidis, View ORCID ProfileRafael Braga Gonçalves
doi: https://doi.org/10.1101/2020.05.13.093781
Carlos Alberto Marques de Carvalho
1Departamento de Patologia, Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará, Belém, PA, Brazil
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  • ORCID record for Carlos Alberto Marques de Carvalho
  • For correspondence: c_marques@live.com
Aline da Rocha Matos
2Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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  • ORCID record for Aline da Rocha Matos
Braulia Costa Caetano
2Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Ivanildo Pedro de Sousa Junior
2Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Samir Pereira da Costa Campos
3Instituto de Tecnologia em Imunobiológicos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Barbara Rodrigues Geraldino
4Coordenação de Prevenção e Vigilância, Instituto Nacional de Câncer José Alencar Gomes da Silva, Rio de Janeiro, RJ, Brazil
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Caroline Augusto Barros
5Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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Matheus Augusto Patricio de Almeida
6Departamento de Bioquímica, Instituto Biomédico, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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Vanessa Pimenta Rocha
6Departamento de Bioquímica, Instituto Biomédico, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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Andréa Marques Vieira da Silva
3Instituto de Tecnologia em Imunobiológicos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Juliana Gil Melgaço
3Instituto de Tecnologia em Imunobiológicos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Patrícia Cristina da Costa Neves
3Instituto de Tecnologia em Imunobiológicos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Tamiris Azamor da Costa Barros
3Instituto de Tecnologia em Imunobiológicos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Ana Paula Dinis Ano Bom
3Instituto de Tecnologia em Imunobiológicos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Marilda Mendonça Siqueira
2Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Sotiris Missailidis
3Instituto de Tecnologia em Imunobiológicos, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
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Rafael Braga Gonçalves
6Departamento de Bioquímica, Instituto Biomédico, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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Abstract

Since its emergence in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been posing a serious threat to public health worldwide as the causative agent of coronavirus disease 2019 (COVID-19). Now distributed in a pandemic pattern, this disease still lacks an effective drug treatment with low toxicity, leading pharmaceutical companies and research labs to work against time to find a candidate molecule to efficiently treat the affected patients. Due to the well-known broad-spectrum antimicrobial activity of the lactoferrin protein, we sought to verify whether its bovine form (bLf) would also be effective in vitro against SARS-CoV-2. Using an antiviral assay based on quantitative reverse transcription-polymerase chain reaction (qRT-PCR), we found that bLf reduced progeny virus yield by up to ∼84,6% in African green monkey kidney epithelial cells (Vero E6) and ∼68,6% in adenocarcinomic human alveolar basal epithelial cells (A549) at 1 mg/mL, a concentration previously shown to have low cytotoxicity. Therefore, our preliminary data suggest that bLf has the potential to constitute a biochemical approach to fight the new coronavirus pandemic.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 13, 2020.
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In Vitro Inhibition of SARS-CoV-2 Infection by Bovine Lactoferrin
Carlos Alberto Marques de Carvalho, Aline da Rocha Matos, Braulia Costa Caetano, Ivanildo Pedro de Sousa Junior, Samir Pereira da Costa Campos, Barbara Rodrigues Geraldino, Caroline Augusto Barros, Matheus Augusto Patricio de Almeida, Vanessa Pimenta Rocha, Andréa Marques Vieira da Silva, Juliana Gil Melgaço, Patrícia Cristina da Costa Neves, Tamiris Azamor da Costa Barros, Ana Paula Dinis Ano Bom, Marilda Mendonça Siqueira, Sotiris Missailidis, Rafael Braga Gonçalves
bioRxiv 2020.05.13.093781; doi: https://doi.org/10.1101/2020.05.13.093781
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In Vitro Inhibition of SARS-CoV-2 Infection by Bovine Lactoferrin
Carlos Alberto Marques de Carvalho, Aline da Rocha Matos, Braulia Costa Caetano, Ivanildo Pedro de Sousa Junior, Samir Pereira da Costa Campos, Barbara Rodrigues Geraldino, Caroline Augusto Barros, Matheus Augusto Patricio de Almeida, Vanessa Pimenta Rocha, Andréa Marques Vieira da Silva, Juliana Gil Melgaço, Patrícia Cristina da Costa Neves, Tamiris Azamor da Costa Barros, Ana Paula Dinis Ano Bom, Marilda Mendonça Siqueira, Sotiris Missailidis, Rafael Braga Gonçalves
bioRxiv 2020.05.13.093781; doi: https://doi.org/10.1101/2020.05.13.093781

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