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Phylogenetic Analysis of SARS-CoV-2 Genomes in Turkey

View ORCID ProfileOgün Adebali, View ORCID ProfileAylin Bircan, View ORCID ProfileDefne Çirci, View ORCID ProfileBurak İşlek, View ORCID ProfileZeynep Kilinç, View ORCID ProfileBerkay Selçuk, View ORCID ProfileBerk Turhan
doi: https://doi.org/10.1101/2020.05.15.095794
Ogün Adebali
Molecular Biology, Genetics and Bioengineering, Faculty of Natural Sciences and Engineering, Sabancı University, İstanbul, Turkey
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  • For correspondence: oadebali@sabanciuniv.edu
Aylin Bircan
Molecular Biology, Genetics and Bioengineering, Faculty of Natural Sciences and Engineering, Sabancı University, İstanbul, Turkey
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Defne Çirci
Molecular Biology, Genetics and Bioengineering, Faculty of Natural Sciences and Engineering, Sabancı University, İstanbul, Turkey
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Burak İşlek
Molecular Biology, Genetics and Bioengineering, Faculty of Natural Sciences and Engineering, Sabancı University, İstanbul, Turkey
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Zeynep Kilinç
Molecular Biology, Genetics and Bioengineering, Faculty of Natural Sciences and Engineering, Sabancı University, İstanbul, Turkey
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Berkay Selçuk
Molecular Biology, Genetics and Bioengineering, Faculty of Natural Sciences and Engineering, Sabancı University, İstanbul, Turkey
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Berk Turhan
Molecular Biology, Genetics and Bioengineering, Faculty of Natural Sciences and Engineering, Sabancı University, İstanbul, Turkey
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Abstract

COVID-19 has effectively spread worldwide. As of May 2020, Turkey is among the top ten countries with the most cases. A comprehensive genomic characterization of the virus isolates in Turkey is yet to be carried out. Here, we built a phylogenetic tree with 15,277 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes. We identified the subtypes based on the phylogenetic clustering in comparison with the previously annotated classifications. We performed a phylogenetic analysis of the first thirty SARS-CoV-2 genomes isolated and sequenced in Turkey. Our results suggest that the first introduction of the virus to the country is earlier than the first reported case of infection. Virus genomes isolated from Turkey are dispersed among most types in the phylogenetic tree. Two of the seventeen sub-clusters were found enriched with the isolates of Turkey, which likely have spread expansively in the country. Finally, we traced virus genomes based on their phylogenetic placements. This analysis suggested multiple independent international introductions of the virus and revealed a hub for the inland transmission. We released a web application to track the global and interprovincial virus spread of the isolates from Turkey in comparison to thousands of genomes worldwide.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted May 15, 2020.
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Phylogenetic Analysis of SARS-CoV-2 Genomes in Turkey
Ogün Adebali, Aylin Bircan, Defne Çirci, Burak İşlek, Zeynep Kilinç, Berkay Selçuk, Berk Turhan
bioRxiv 2020.05.15.095794; doi: https://doi.org/10.1101/2020.05.15.095794
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Phylogenetic Analysis of SARS-CoV-2 Genomes in Turkey
Ogün Adebali, Aylin Bircan, Defne Çirci, Burak İşlek, Zeynep Kilinç, Berkay Selçuk, Berk Turhan
bioRxiv 2020.05.15.095794; doi: https://doi.org/10.1101/2020.05.15.095794

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