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SARS-CoV2 infection in farmed mink, Netherlands, April 2020

View ORCID ProfileNadia Oreshkova, Robert-Jan Molenaar, Sandra Vreman, Frank Harders, Bas B. Oude Munnink, Renate Hakze, Nora Gerhards, Paulien Tolsma, Ruth Bouwstra, Reina Sikkema, Mirriam Tacken, Myrna M.T. de Rooij, Eefke Weesendorp, Marc Engelsma, Christianne Bruschke, Lidwien A.M. Smit, Marion Koopmans, Wim H.M. van der Poel, Arjan Stegeman
doi: https://doi.org/10.1101/2020.05.18.101493
Nadia Oreshkova
1Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands
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  • ORCID record for Nadia Oreshkova
Robert-Jan Molenaar
2GD Animal Health, Deventer, The Netherlands
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Sandra Vreman
1Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands
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Frank Harders
1Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands
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Bas B. Oude Munnink
3Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
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Renate Hakze
1Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands
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Nora Gerhards
1Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands
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Paulien Tolsma
4Regional Public Health Service Brabant-Zuid-Oost, Eindhoven, The Netherlands
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Ruth Bouwstra
2GD Animal Health, Deventer, The Netherlands
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Reina Sikkema
3Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
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Mirriam Tacken
1Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands
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Myrna M.T. de Rooij
5Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands
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Eefke Weesendorp
1Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands
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Marc Engelsma
1Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands
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Christianne Bruschke
6Ministry of Agriculture, Nature and Food Quality, The Hague, The Netherlands
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Lidwien A.M. Smit
5Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands
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Marion Koopmans
3Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
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Wim H.M. van der Poel
1Wageningen Bioveterinary Research, Wageningen University and Research, Lelystad, The Netherlands
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  • For correspondence: wim.vanderpoel@wur.nl
Arjan Stegeman
8Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
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Abstract

In April 2020, respiratory disease and increased mortality were observed in farmed mink on two farms in the Netherlands. In both farms, at least one worker had been found positive for SARS-CoV-2. Necropsies of the mink revealed interstitial pneumonia, and organ and swab samples tested positive for SARS-CoV-2 RNA by qPCR. Variations in viral genomes point at between-mink transmission on the farms and lack of infection link between the farms. Inhalable dust in the mink houses contained viral RNA, indicating possible exposure of workers.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 18, 2020.
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SARS-CoV2 infection in farmed mink, Netherlands, April 2020
Nadia Oreshkova, Robert-Jan Molenaar, Sandra Vreman, Frank Harders, Bas B. Oude Munnink, Renate Hakze, Nora Gerhards, Paulien Tolsma, Ruth Bouwstra, Reina Sikkema, Mirriam Tacken, Myrna M.T. de Rooij, Eefke Weesendorp, Marc Engelsma, Christianne Bruschke, Lidwien A.M. Smit, Marion Koopmans, Wim H.M. van der Poel, Arjan Stegeman
bioRxiv 2020.05.18.101493; doi: https://doi.org/10.1101/2020.05.18.101493
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SARS-CoV2 infection in farmed mink, Netherlands, April 2020
Nadia Oreshkova, Robert-Jan Molenaar, Sandra Vreman, Frank Harders, Bas B. Oude Munnink, Renate Hakze, Nora Gerhards, Paulien Tolsma, Ruth Bouwstra, Reina Sikkema, Mirriam Tacken, Myrna M.T. de Rooij, Eefke Weesendorp, Marc Engelsma, Christianne Bruschke, Lidwien A.M. Smit, Marion Koopmans, Wim H.M. van der Poel, Arjan Stegeman
bioRxiv 2020.05.18.101493; doi: https://doi.org/10.1101/2020.05.18.101493

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