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The Surprising Role of the Default Mode Network

View ORCID ProfileT. Brandman, R. Malach, E. Simony.
doi: https://doi.org/10.1101/2020.05.18.101758
T. Brandman
1Department of Neurobiology and the Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science
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  • For correspondence: talli.brandman@gmail.com
R. Malach
1Department of Neurobiology and the Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science
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E. Simony.
1Department of Neurobiology and the Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science
2Faculty of Engineering, Holon Institute of Technology
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Abstract

The default mode network (DMN) is a group of high-order brain regions recently implicated in processing external naturalistic events, yet it remains unclear what cognitive function it serves. Here we identified the cognitive states predictive of DMN fMRI coactivation. Particularly, we developed a state-fluctuation pattern analysis, matching network coactivations across a short movie with retrospective behavioral sampling of movie events. Network coactivation was selectively correlated with the state of surprise across movie events, compared to all other cognitive states (e.g. emotion, vividness). The effect was exhibited in the DMN, but not dorsal attention or visual networks. Furthermore, surprise was found to mediate DMN coactivations with hippocampus and nucleus accumbens. These unexpected findings point to the DMN as a major hub in high-level prediction-error representations.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 15, 2020.
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The Surprising Role of the Default Mode Network
T. Brandman, R. Malach, E. Simony.
bioRxiv 2020.05.18.101758; doi: https://doi.org/10.1101/2020.05.18.101758
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The Surprising Role of the Default Mode Network
T. Brandman, R. Malach, E. Simony.
bioRxiv 2020.05.18.101758; doi: https://doi.org/10.1101/2020.05.18.101758

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