Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Iain Mathieson; Felix R. Day; Nicola Barban; Felix C. Tropf; David M. Brazel; eQTLGen Consortium; BIOS Consortium; Ahmad Vaez; Natalie van Zuydam; Bárbara D. Bitarello; Harold Snieder; Marcel den Hoed; Ken K. Ong; Melinda C. Mills; John R.B. Perry; on behalf of the Human Reproductive Behaviour Consortium

doi:10.1101/2020.05.19.104455

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Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, eQTLGen Consortium, BIOS Consortium, Ahmad Vaez, Natalie van Zuydam, Bárbara D. Bitarello, Harold Snieder, Marcel den Hoed, Ken K. Ong, Melinda C. Mills, John R.B. Perry, on behalf of the Human Reproductive Behaviour Consortium

doi: https://doi.org/10.1101/2020.05.19.104455

Iain Mathieson

1Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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For correspondence: mathi@pennmedicine.upenn.edu melinda.mills@nuffield.ox.ac.uk john.perry@mrc-epid.cam.ac.uk

Felix R. Day

2MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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Nicola Barban

3Institute of Social and Economic Research, University of Essex, Essex, United Kingdom

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Felix C. Tropf

4Leverhulme Centre for Demographic Science, University of Oxford, Oxford, United Kingdom

5Nuffield College, University of Oxford, Oxford, United Kingdom

6École Nationale de la Statistique et de L’administration Économique (ENSAE), Paris, France

7Center for Research in Economics and Statistics (CREST), Paris, France

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David M. Brazel

4Leverhulme Centre for Demographic Science, University of Oxford, Oxford, United Kingdom

5Nuffield College, University of Oxford, Oxford, United Kingdom

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Ahmad Vaez

8Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

9Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran

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Natalie van Zuydam

10The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden

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Bárbara D. Bitarello

1Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America

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Harold Snieder

8Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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Marcel den Hoed

10The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden

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Ken K. Ong

2MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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Melinda C. Mills

4Leverhulme Centre for Demographic Science, University of Oxford, Oxford, United Kingdom

5Nuffield College, University of Oxford, Oxford, United Kingdom

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For correspondence: mathi@pennmedicine.upenn.edu melinda.mills@nuffield.ox.ac.uk john.perry@mrc-epid.cam.ac.uk

John R.B. Perry

2MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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For correspondence: mathi@pennmedicine.upenn.edu melinda.mills@nuffield.ox.ac.uk john.perry@mrc-epid.cam.ac.uk