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RdRp mutations are associated with SARS-CoV-2 genome evolution

Doğa Eskier, Gökhan Karakülah, Aslı Suner, Yavuz Oktay
doi: https://doi.org/10.1101/2020.05.20.104885
Doğa Eskier
1İzmir Biomedicine and Genome Center (IBG), 35340, İnciraltı, İzmir, Turkey
2İzmir International Biomedicine and Genome Institute (iBG-İzmir), Dokuz Eylül University, 35340, İnciraltı, İzmir, Turkey
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Gökhan Karakülah
1İzmir Biomedicine and Genome Center (IBG), 35340, İnciraltı, İzmir, Turkey
2İzmir International Biomedicine and Genome Institute (iBG-İzmir), Dokuz Eylül University, 35340, İnciraltı, İzmir, Turkey
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Aslı Suner
3Department of Biostatistics and Medical Informatics, Faculty of Medicine, Ege University, İzmir, Turkey
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Yavuz Oktay
1İzmir Biomedicine and Genome Center (IBG), 35340, İnciraltı, İzmir, Turkey
2İzmir International Biomedicine and Genome Institute (iBG-İzmir), Dokuz Eylül University, 35340, İnciraltı, İzmir, Turkey
4Faculty of Medicine, Department of Medical Biology, Dokuz Eylül University, 35340, İnciraltı, İzmir, Turkey
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  • For correspondence: yavuz.oktay@ibg.edu.tr
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Abstract

COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of viral genome over time as it spread across the world. An important question that still needs to be answered is whether any of the common mutations affect the viral properties, and therefore the disease characteristics. Therefore, we sought to understand the effects of mutations in RNA-dependent RNA polymerase (RdRp), particularly the common 14408C>T mutation, on mutation rate and viral spread. By focusing on mutations in the slowly evolving M or E genes, we aimed to minimize the effects of selective pressure. Our results indicate that 14408C>T mutation increases the mutation rate, while the third-most common RdRp mutation, 15324C>T, has the opposite effect. It is possible that 14408C>T mutation may have contributed to the dominance of its co-mutations in Europe and elsewhere.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 20, 2020.
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RdRp mutations are associated with SARS-CoV-2 genome evolution
Doğa Eskier, Gökhan Karakülah, Aslı Suner, Yavuz Oktay
bioRxiv 2020.05.20.104885; doi: https://doi.org/10.1101/2020.05.20.104885
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RdRp mutations are associated with SARS-CoV-2 genome evolution
Doğa Eskier, Gökhan Karakülah, Aslı Suner, Yavuz Oktay
bioRxiv 2020.05.20.104885; doi: https://doi.org/10.1101/2020.05.20.104885

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