1. Abstract
Cacaoidin is the first member of the new lanthidin RiPP family, a lanthipeptide produced by the strain Streptomyces cacaoi CA-170360 with unprecedented features such as an unusually high number of D-amino acids, a double methylation in the N-terminal alanine and a tyrosine residue glycosylated with a disaccharide. In this work, we describe the complete identification, cloning and heterologous expression of the cacaoidin biosynthetic gene cluster, which shows unique RiPP genes.
Competing Interest Statement
The authors have declared no competing interest.
Copyright
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Posted May 22, 2020.
Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs
