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Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs

Fernando Román-Hurtado, View ORCID ProfileMarina Sánchez-Hidalgo, View ORCID ProfileJesús Martín, View ORCID ProfileFrancisco Javier Ortíz-López, View ORCID ProfileOlga Genilloud
doi: https://doi.org/10.1101/2020.05.20.105809
Fernando Román-Hurtado
1Fundación MEDINA, Avenida del Conocimiento 34, 18016 Granada, Spain; (F.R.H); (M.S.H); (J.M); (F.J.O); (O.G)
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  • For correspondence: fernando.roman@medinaandalucia.es marina.sanchez@medinaandalucia.es jesus.martin@medinaandalucia.es javier.ortiz@medinaandalucia.es olga.genilloud@medinaandalucia.es
Marina Sánchez-Hidalgo
1Fundación MEDINA, Avenida del Conocimiento 34, 18016 Granada, Spain; (F.R.H); (M.S.H); (J.M); (F.J.O); (O.G)
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  • ORCID record for Marina Sánchez-Hidalgo
  • For correspondence: marina.sanchez@medinaandalucia.es fernando.roman@medinaandalucia.es marina.sanchez@medinaandalucia.es jesus.martin@medinaandalucia.es javier.ortiz@medinaandalucia.es olga.genilloud@medinaandalucia.es
Jesús Martín
1Fundación MEDINA, Avenida del Conocimiento 34, 18016 Granada, Spain; (F.R.H); (M.S.H); (J.M); (F.J.O); (O.G)
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  • ORCID record for Jesús Martín
  • For correspondence: fernando.roman@medinaandalucia.es marina.sanchez@medinaandalucia.es jesus.martin@medinaandalucia.es javier.ortiz@medinaandalucia.es olga.genilloud@medinaandalucia.es
Francisco Javier Ortíz-López
1Fundación MEDINA, Avenida del Conocimiento 34, 18016 Granada, Spain; (F.R.H); (M.S.H); (J.M); (F.J.O); (O.G)
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  • For correspondence: fernando.roman@medinaandalucia.es marina.sanchez@medinaandalucia.es jesus.martin@medinaandalucia.es javier.ortiz@medinaandalucia.es olga.genilloud@medinaandalucia.es
Olga Genilloud
1Fundación MEDINA, Avenida del Conocimiento 34, 18016 Granada, Spain; (F.R.H); (M.S.H); (J.M); (F.J.O); (O.G)
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  • ORCID record for Olga Genilloud
  • For correspondence: marina.sanchez@medinaandalucia.es fernando.roman@medinaandalucia.es marina.sanchez@medinaandalucia.es jesus.martin@medinaandalucia.es javier.ortiz@medinaandalucia.es olga.genilloud@medinaandalucia.es
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1. Abstract

Cacaoidin is the first member of the new lanthidin RiPP family, a lanthipeptide produced by the strain Streptomyces cacaoi CA-170360 with unprecedented features such as an unusually high number of D-amino acids, a double methylation in the N-terminal alanine and a tyrosine residue glycosylated with a disaccharide. In this work, we describe the complete identification, cloning and heterologous expression of the cacaoidin biosynthetic gene cluster, which shows unique RiPP genes.

Competing Interest Statement

The authors have declared no competing interest.

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Posted May 22, 2020.
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Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs
Fernando Román-Hurtado, Marina Sánchez-Hidalgo, Jesús Martín, Francisco Javier Ortíz-López, Olga Genilloud
bioRxiv 2020.05.20.105809; doi: https://doi.org/10.1101/2020.05.20.105809
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Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs
Fernando Román-Hurtado, Marina Sánchez-Hidalgo, Jesús Martín, Francisco Javier Ortíz-López, Olga Genilloud
bioRxiv 2020.05.20.105809; doi: https://doi.org/10.1101/2020.05.20.105809

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