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- May 23, 2020.
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- Mayte Suárez-Fariñas+,1,2,
- Minami Tokuyama+,3,4,
- Gabrielle Wei1,2,
- Ruiqi Huang1,2,
- Alexandra Livanos3,4,
- Divya Jha3,4,
- Anais Levescot5,6,
- Roman Kosoy1,2,
- Haritz Irizar7,
- Sascha Cording5,6,
- Wenhui Wang1,2,
- Ryan Ungaro3,
- Antonio Di’Narzo1,2,
- Gustavo Martinez3,4,
- Maria Suprun1,
- Michael J. Corley8,
- Aleksandar Stojmirovic9,
- Sander M. Houten1,2,
- Mark Curran9,
- Carrie Brodmerkel9,
- Jacqueline Perrigoue9,
- Joshua R. Friedman9,
- Ke Hao1,2,
- Eric E. Schadt1,2,
- Jun Zhu1,2,
- Huaibin M. Ko11,
- Judy Cho2,3,10,
- Marla C. Dubinsky3,
- Bruce E. Sands3,
- Lishomwa Ndhlovu8,
- Nadine Cerf-Benssusan5,6,
- Andrew Kasarskis1,2,
- Jean Frederic Colombel3,4,
- Noam Harpaz11,
- Carmen Argmann*,1,2 and
- Saurabh Mehandru*,3,4
- 1Center for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 2Icahn Institute for Data Science and Genomic Technology, New York City, NY, USA
- 3The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 4Precision Institute of Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 5Inserm, UMR1163, Laboratory of Intestinal Immunity and Institute Imagine, Paris, France
- 6Université de Paris, Paris, France
- 7University College London, Department Mental Health Sciences Unit, London, UK
- 8Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA
- 9Janssen R&D, Spring House, PA, USA
- 10The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 11Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- ↵*Address correspondence to saurabh.mehandru{at}mssm.edu and carmen.argmann{at}mssm.edu
↵+ Contributed equally
Author contributions: SM, AC, MSF, MT, GW and DJ drafted the manuscript. SM, AC and MSF designed the study, supervised experimental data collection and coordinated integration of collaboration between all participating laboratories. MT performed immunostaining experiments. GW performed network analysis experiments and RH performed statistical analyses. WW, AD, KH, JZ were involved in various aspects of data generation, curation or analysis. All authors critically reviewed and edited the final version of the manuscript.