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Integrated cross-study datasets of genetic dependencies in cancer

Clare Pacini, View ORCID ProfileJoshua M. Dempster, Isabella Boyle, View ORCID ProfileEmanuel Gonçalves, View ORCID ProfileHanna Najgebauer, View ORCID ProfileEmre Karakoc, View ORCID ProfileDieudonne van der Meer, Andrew Barthorpe, View ORCID ProfileHoward Lightfoot, Patricia Jaaks, James M. McFarland, Mathew J. Garnett, View ORCID ProfileAviad Tsherniak, View ORCID ProfileFrancesco Iorio
doi: https://doi.org/10.1101/2020.05.22.110247
Clare Pacini
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
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Joshua M. Dempster
3Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA
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  • ORCID record for Joshua M. Dempster
Isabella Boyle
3Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA
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Emanuel Gonçalves
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
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  • ORCID record for Emanuel Gonçalves
Hanna Najgebauer
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
4European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
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  • ORCID record for Hanna Najgebauer
Emre Karakoc
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
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  • ORCID record for Emre Karakoc
Dieudonne van der Meer
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
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  • ORCID record for Dieudonne van der Meer
Andrew Barthorpe
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
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Howard Lightfoot
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
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  • ORCID record for Howard Lightfoot
Patricia Jaaks
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
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James M. McFarland
3Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA
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Mathew J. Garnett
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
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Aviad Tsherniak
3Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA
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  • ORCID record for Aviad Tsherniak
Francesco Iorio
1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
5Human Technopole, Via Cristina Belgioioso 147, 20157 Milano - Italy
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  • ORCID record for Francesco Iorio
  • For correspondence: francesco.iorio@sanger.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2020.05.22.110247
History 
  • January 6, 2021.

Article Versions

  • Version 1 (May 23, 2020 - 02:13).
  • Version 2 (May 25, 2020 - 03:49).
  • You are viewing Version 3, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Clare Pacini1,2,
  2. Joshua M. Dempster3,
  3. Isabella Boyle3,
  4. Emanuel Gonçalves1,
  5. Hanna Najgebauer1,2,4,
  6. Emre Karakoc1,2,
  7. Dieudonne van der Meer1,
  8. Andrew Barthorpe1,
  9. Howard Lightfoot1,
  10. Patricia Jaaks1,
  11. James M. McFarland3,
  12. Mathew J. Garnett1,2,
  13. Aviad Tsherniak3 and
  14. Francesco Iorio1,2,5,*
  1. 1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
  2. 2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
  3. 3Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA
  4. 4European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK
  5. 5Human Technopole, Via Cristina Belgioioso 147, 20157 Milano - Italy
  1. ↵*Corresponding author: francesco.iorio{at}sanger.ac.uk
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Integrated cross-study datasets of genetic dependencies in cancer
Clare Pacini, Joshua M. Dempster, Isabella Boyle, Emanuel Gonçalves, Hanna Najgebauer, Emre Karakoc, Dieudonne van der Meer, Andrew Barthorpe, Howard Lightfoot, Patricia Jaaks, James M. McFarland, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio
bioRxiv 2020.05.22.110247; doi: https://doi.org/10.1101/2020.05.22.110247
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Integrated cross-study datasets of genetic dependencies in cancer
Clare Pacini, Joshua M. Dempster, Isabella Boyle, Emanuel Gonçalves, Hanna Najgebauer, Emre Karakoc, Dieudonne van der Meer, Andrew Barthorpe, Howard Lightfoot, Patricia Jaaks, James M. McFarland, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio
bioRxiv 2020.05.22.110247; doi: https://doi.org/10.1101/2020.05.22.110247

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