Integrated cross-study datasets of genetic dependencies in cancer

Clare Pacini; Joshua M. Dempster; Isabella Boyle; Emanuel Gonçalves; Hanna Najgebauer; Emre Karakoc; Dieudonne van der Meer; Andrew Barthorpe; Howard Lightfoot; Patricia Jaaks; James M. McFarland; Mathew J. Garnett; Aviad Tsherniak; Francesco Iorio

doi:10.1101/2020.05.22.110247

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Integrated cross-study datasets of genetic dependencies in cancer

Clare Pacini, View ORCID ProfileJoshua M. Dempster, Isabella Boyle, View ORCID ProfileEmanuel Gonçalves, View ORCID ProfileHanna Najgebauer, View ORCID ProfileEmre Karakoc, View ORCID ProfileDieudonne van der Meer, Andrew Barthorpe, View ORCID ProfileHoward Lightfoot, Patricia Jaaks, James M. McFarland, Mathew J. Garnett, View ORCID ProfileAviad Tsherniak, View ORCID ProfileFrancesco Iorio

doi: https://doi.org/10.1101/2020.05.22.110247

Clare Pacini

1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

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Joshua M. Dempster

3Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA

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Isabella Boyle

3Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA

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Emanuel Gonçalves

1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

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Hanna Najgebauer

1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

4European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK

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Emre Karakoc

1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

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Dieudonne van der Meer

1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

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Andrew Barthorpe

1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

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Howard Lightfoot

1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

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Patricia Jaaks

1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

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James M. McFarland

3Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA

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Mathew J. Garnett

1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

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Aviad Tsherniak

3Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA

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Francesco Iorio

1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

2Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

5Human Technopole, Via Cristina Belgioioso 147, 20157 Milano - Italy

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For correspondence: francesco.iorio@sanger.ac.uk

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Integrated cross-study datasets of genetic dependencies in cancer

Clare Pacini, Joshua M. Dempster, Isabella Boyle, Emanuel Gonçalves, Hanna Najgebauer, Emre Karakoc, Dieudonne van der Meer, Andrew Barthorpe, Howard Lightfoot, Patricia Jaaks, James M. McFarland, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio

bioRxiv 2020.05.22.110247; doi: https://doi.org/10.1101/2020.05.22.110247

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