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COVIDep platform for real-time reporting of vaccine target recommendations for SARS-CoV-2: Description and connections with COVID-19 immune responses and preclinical vaccine trials

View ORCID ProfileSyed Faraz Ahmed, View ORCID ProfileAhmed A. Quadeer, View ORCID ProfileMatthew R. McKay
doi: https://doi.org/10.1101/2020.05.23.111385
Syed Faraz Ahmed
1Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
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Ahmed A. Quadeer
1Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
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  • For correspondence: eeaaquadeer@ust.hk m.mckay@ust.hk
Matthew R. McKay
1Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
2Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
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  • For correspondence: eeaaquadeer@ust.hk m.mckay@ust.hk
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Abstract

We introduce COVIDep (https://COVIDep.ust.hk), a web-based platform that provides immune target recommendations for guiding SARS-CoV-2 vaccine development. COVIDep implements a protocol that pools together publicly-available genetic data for SARS-CoV-2 and epitope data for SARS-CoV to identify B cell and T cell epitopes that present potential immune targets for SARS-CoV-2. Correspondences between outputs of COVIDep and immune responses recorded in COVID-19 patients and preclinical vaccine trials are also indicated. The platform is user-friendly, flexible, and based on up-to-date data. It may help guide vaccine designs and associated experimental studies for SARS-CoV-2.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Updated the title.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted June 04, 2020.
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COVIDep platform for real-time reporting of vaccine target recommendations for SARS-CoV-2: Description and connections with COVID-19 immune responses and preclinical vaccine trials
Syed Faraz Ahmed, Ahmed A. Quadeer, Matthew R. McKay
bioRxiv 2020.05.23.111385; doi: https://doi.org/10.1101/2020.05.23.111385
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COVIDep platform for real-time reporting of vaccine target recommendations for SARS-CoV-2: Description and connections with COVID-19 immune responses and preclinical vaccine trials
Syed Faraz Ahmed, Ahmed A. Quadeer, Matthew R. McKay
bioRxiv 2020.05.23.111385; doi: https://doi.org/10.1101/2020.05.23.111385

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