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Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system

View ORCID ProfileLukasz Jablonski, View ORCID ProfileTamas Harczos, Bettina Wolf, Gerhard Hoch, Alexander Dieter, Roland Hessler, Suleman Ayub, Patrick Ruther, View ORCID ProfileTobias Moser
doi: https://doi.org/10.1101/2020.05.25.114868
Lukasz Jablonski
1Institute for Auditory Neuroscience, University Medical Center Göttingen, Göttingen, Germany
2Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany
3InnerEarLab, University Medical Center Göttingen, Göttingen, Germany
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  • ORCID record for Lukasz Jablonski
Tamas Harczos
1Institute for Auditory Neuroscience, University Medical Center Göttingen, Göttingen, Germany
2Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany
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Bettina Wolf
1Institute for Auditory Neuroscience, University Medical Center Göttingen, Göttingen, Germany
2Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany
3InnerEarLab, University Medical Center Göttingen, Göttingen, Germany
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Gerhard Hoch
1Institute for Auditory Neuroscience, University Medical Center Göttingen, Göttingen, Germany
3InnerEarLab, University Medical Center Göttingen, Göttingen, Germany
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Alexander Dieter
1Institute for Auditory Neuroscience, University Medical Center Göttingen, Göttingen, Germany
3InnerEarLab, University Medical Center Göttingen, Göttingen, Germany
4Göttingen Graduate School for Neurosciences and Molecular Biosciences, University of Göttingen, Göttingen, Germany
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Roland Hessler
5MED-EL, Innsbruck, Austria
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Suleman Ayub
6Department of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg, Germany
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Patrick Ruther
6Department of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg, Germany
7BrainLinks-BrainTools, Cluster of Excellence, University of Freiburg, 79110 Freiburg, Germany
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Tobias Moser
1Institute for Auditory Neuroscience, University Medical Center Göttingen, Göttingen, Germany
2Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany
3InnerEarLab, University Medical Center Göttingen, Göttingen, Germany
8Auditory Neuroscience Group, Max Planck Institute for Experimental Medicine, Göttingen, Germany
9Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, Göttingen, Germany
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  • For correspondence: tmoser@gwdg.de
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Abstract

In case of deafness, cochlear implants bypass dysfunctional or lost hair cells by direct electrical stimulation (eCIs) of the auditory nerve. However, spectral selectivity of eCI sound coding is low as the wide current spread from each electrode activates large sets of neurons that align to a place-frequency (tonotopic) map in the cochlea. As light can be better confined in space, optical cochlear implants (oCIs) promise to overcome this shortcoming of eCIs. This requires fine-grained, fast, and power-efficient real-time sound analysis and control of multiple microscale emitters. Here, we describe the development, characterisation, and application for hearing restoration of a preclinical low-weight and wireless LED-based multichannel oCI system and its companion eCI system. The head-worn oCI system enabled deaf rats to perform a locomotion task in response to acoustic stimulation proofing of concept of multichannel optogenetic hearing restoration in rodents.

Competing Interest Statement

T.M. is a co-founder of OptoGenTech GmbH.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 27, 2020.
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Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system
Lukasz Jablonski, Tamas Harczos, Bettina Wolf, Gerhard Hoch, Alexander Dieter, Roland Hessler, Suleman Ayub, Patrick Ruther, Tobias Moser
bioRxiv 2020.05.25.114868; doi: https://doi.org/10.1101/2020.05.25.114868
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Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system
Lukasz Jablonski, Tamas Harczos, Bettina Wolf, Gerhard Hoch, Alexander Dieter, Roland Hessler, Suleman Ayub, Patrick Ruther, Tobias Moser
bioRxiv 2020.05.25.114868; doi: https://doi.org/10.1101/2020.05.25.114868

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