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Dynamics of mutual inhibition between two visual cortical neurons compared to human perceptual competition

View ORCID ProfileNaoki Kogo, Felix B. Kern, View ORCID ProfileThomas Nowotny, Raymond van Ee, Richard van Wezel, Takeshi Aihara
doi: https://doi.org/10.1101/2020.05.26.113324
Naoki Kogo
1Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands
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  • For correspondence: naoki.kogo@gmail.com
Felix B. Kern
2School of Life Sciences, Sussex Neuroscience, University of Sussex, UK
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Thomas Nowotny
3School of Engineering and Informatics, University of Sussex, UK
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Raymond van Ee
4Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands
5Brain and Cognition, University of Leuven, Belgium
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Richard van Wezel
1Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands
6Biomedical Signals and Systems, MedTech Centre, University of Twente, The Netherlands
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Takeshi Aihara
7Graduate School of Brain Sciences, Tamagawa University, Japan
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Abstract

Visual perception emerges as the result of neural systems actively organizing intrinsically noisy visual signals. It is commonly assumed that selection processes of competing neurons underlie this emergence of perceptual organization. While the neural competition, realized by such a “mutual inhibition” circuit has been examined in many theoretical studies, its dynamic properties have not been investigated in real neurons. We have developed a “hybrid” system where two real-life pyramidal neurons in a mouse brain slice interact through a computer simulated mutual inhibition circuit. We found that simultaneous activation of the mutually inhibiting pyramidal neurons leads to bi-stable activity. We investigated the effects of noise and the effect of changes in the activation strength on the dynamics. We observed that the circuit exhibits dynamics strikingly similar to the known properties of bi-stable visual perception.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted May 27, 2020.
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Dynamics of mutual inhibition between two visual cortical neurons compared to human perceptual competition
Naoki Kogo, Felix B. Kern, Thomas Nowotny, Raymond van Ee, Richard van Wezel, Takeshi Aihara
bioRxiv 2020.05.26.113324; doi: https://doi.org/10.1101/2020.05.26.113324
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Dynamics of mutual inhibition between two visual cortical neurons compared to human perceptual competition
Naoki Kogo, Felix B. Kern, Thomas Nowotny, Raymond van Ee, Richard van Wezel, Takeshi Aihara
bioRxiv 2020.05.26.113324; doi: https://doi.org/10.1101/2020.05.26.113324

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