Novel heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase

Gloria Gamiz-Arco; Luis I. Gutierrez-Rus; Valeria A. Risso; Beatriz Ibarra-Molero; Yosuke Hoshino; Dušan Petrović; Adrian Romero-Rivera; Burckhard Seelig; Jose A. Gavira; Shina C.L. Kamerlin; Eric A. Gaucher; Jose M. Sanchez-Ruiz

doi:10.1101/2020.05.27.118968

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Novel heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase

Gloria Gamiz-Arco, Luis I. Gutierrez-Rus, Valeria A. Risso, Beatriz Ibarra-Molero, Yosuke Hoshino, Dušan Petrović, Adrian Romero-Rivera, Burckhard Seelig, Jose A. Gavira, Shina C.L. Kamerlin, Eric A. Gaucher, Jose M. Sanchez-Ruiz

doi: https://doi.org/10.1101/2020.05.27.118968

Gloria Gamiz-Arco

1Departamento de Quimica Fisica. Facultad de Ciencias, Unidad de Excelencia de Quimica Aplicada a Biomedicina y Medioambiente (UEQ), Universidad de Granada, 18071 Granada, Spain

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Luis I. Gutierrez-Rus

1Departamento de Quimica Fisica. Facultad de Ciencias, Unidad de Excelencia de Quimica Aplicada a Biomedicina y Medioambiente (UEQ), Universidad de Granada, 18071 Granada, Spain

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Valeria A. Risso

1Departamento de Quimica Fisica. Facultad de Ciencias, Unidad de Excelencia de Quimica Aplicada a Biomedicina y Medioambiente (UEQ), Universidad de Granada, 18071 Granada, Spain

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Beatriz Ibarra-Molero

1Departamento de Quimica Fisica. Facultad de Ciencias, Unidad de Excelencia de Quimica Aplicada a Biomedicina y Medioambiente (UEQ), Universidad de Granada, 18071 Granada, Spain

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Yosuke Hoshino

2Department of Biology, Georgia State University, Atlanta, GA 30306 U.S.A.

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Dušan Petrović

3Science for Life Laboratory, Department of Chemistry-BMC, Uppsala University, BMC Box 576, S-751 23 Uppsala, Sweden

7Hit Discovery, Discovery Sciences, Biopharmaceutical R&D, AstraZeneca, 431 50 Gothenburg, Sweden

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Adrian Romero-Rivera

3Science for Life Laboratory, Department of Chemistry-BMC, Uppsala University, BMC Box 576, S-751 23 Uppsala, Sweden

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Burckhard Seelig

4Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America, & BioTechnology Institute, University of Minnesota, St. Paul, Minnesota, United States of America

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Jose A. Gavira

5Laboratorio de Estudios Cristalograficos, Instituto Andaluz de Ciencias de la Tierra, CSIC, Unidad de Excelencia de Quimica Aplicada a Biomedicina y Medioambiente (UEQ), Universidad de Granada, Avenida de las Palmeras 4, Granada 18100 Armilla, Spain

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Shina C.L. Kamerlin

3Science for Life Laboratory, Department of Chemistry-BMC, Uppsala University, BMC Box 576, S-751 23 Uppsala, Sweden

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Eric A. Gaucher

2Department of Biology, Georgia State University, Atlanta, GA 30306 U.S.A.

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Jose M. Sanchez-Ruiz

1Departamento de Quimica Fisica. Facultad de Ciencias, Unidad de Excelencia de Quimica Aplicada a Biomedicina y Medioambiente (UEQ), Universidad de Granada, 18071 Granada, Spain