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Comprehensive Transcriptomic Analysis of COVID-19 Blood, Lung, and Airway

View ORCID ProfileAndrea R. Daamen, Prathyusha Bachali, Katherine A. Owen, Kathryn M. Kingsmore, Erika L. Hubbard, Adam C. Labonte, Robert Robl, Sneha Shrotri, Amrie C. Grammer, Peter E. Lipsky
doi: https://doi.org/10.1101/2020.05.28.121889
Andrea R. Daamen
1AMPEL BioSolutions LLC; Charlottesville, Virginia, 22902; United States of America
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  • For correspondence: peterlipsky@comcast.net andrea.daamen@ampelbiosolutions.com
Prathyusha Bachali
1AMPEL BioSolutions LLC; Charlottesville, Virginia, 22902; United States of America
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Katherine A. Owen
1AMPEL BioSolutions LLC; Charlottesville, Virginia, 22902; United States of America
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Kathryn M. Kingsmore
1AMPEL BioSolutions LLC; Charlottesville, Virginia, 22902; United States of America
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Erika L. Hubbard
1AMPEL BioSolutions LLC; Charlottesville, Virginia, 22902; United States of America
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Adam C. Labonte
1AMPEL BioSolutions LLC; Charlottesville, Virginia, 22902; United States of America
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Robert Robl
1AMPEL BioSolutions LLC; Charlottesville, Virginia, 22902; United States of America
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Sneha Shrotri
1AMPEL BioSolutions LLC; Charlottesville, Virginia, 22902; United States of America
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Amrie C. Grammer
1AMPEL BioSolutions LLC; Charlottesville, Virginia, 22902; United States of America
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Peter E. Lipsky
1AMPEL BioSolutions LLC; Charlottesville, Virginia, 22902; United States of America
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  • For correspondence: peterlipsky@comcast.net andrea.daamen@ampelbiosolutions.com
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Abstract

Abstract SARS-CoV2 is a previously uncharacterized coronavirus and causative agent of the COVID-19 pandemic. The host response to SARS-CoV2 has not yet been fully delineated, hampering a precise approach to therapy. To address this, we carried out a comprehensive analysis of gene expression data from the blood, lung, and airway of COVID-19 patients. Our results indicate that COVID-19 pathogenesis is driven by populations of myeloid-lineage cells with highly inflammatory but distinct transcriptional signatures in each compartment. The relative absence of cytotoxic cells in the lung suggests a model in which delayed clearance of the virus may permit exaggerated myeloid cell activation that contributes to disease pathogenesis by the production of inflammatory mediators. The gene expression profiles also identify potential therapeutic targets that could be modified with available drugs. The data suggest that transcriptomic profiling can provide an understanding of the pathogenesis of COVID-19 in individual patients.

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Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵3 Lead Contact

  • https://bigd.big.ac.cn/gsa/browse/CRA002390

  • https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147507

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Posted May 28, 2020.
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Comprehensive Transcriptomic Analysis of COVID-19 Blood, Lung, and Airway
Andrea R. Daamen, Prathyusha Bachali, Katherine A. Owen, Kathryn M. Kingsmore, Erika L. Hubbard, Adam C. Labonte, Robert Robl, Sneha Shrotri, Amrie C. Grammer, Peter E. Lipsky
bioRxiv 2020.05.28.121889; doi: https://doi.org/10.1101/2020.05.28.121889
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Comprehensive Transcriptomic Analysis of COVID-19 Blood, Lung, and Airway
Andrea R. Daamen, Prathyusha Bachali, Katherine A. Owen, Kathryn M. Kingsmore, Erika L. Hubbard, Adam C. Labonte, Robert Robl, Sneha Shrotri, Amrie C. Grammer, Peter E. Lipsky
bioRxiv 2020.05.28.121889; doi: https://doi.org/10.1101/2020.05.28.121889

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