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The Caribbean-Hispanic Alzheimer’s Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms

Daniel Felsky, Sanjeev Sariya, Ismael Santa-Maria, Leon French, Julie A. Schneider, David A. Bennett, Richard Mayeux, Philip L. De Jager, Giuseppe Tosto
doi: https://doi.org/10.1101/2020.05.28.122234
Daniel Felsky
1Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, 250 College St., M5T 1R8, Canada
2Department of Psychiatry, University of Toronto, Toronto, ON, 27 King’s College Circle Toronto, Ontario M5S 1A1 Canada
3Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
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Sanjeev Sariya
4The Department of Neurology and The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
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Ismael Santa-Maria
5Department of Pathology and Cell Biology, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
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Leon French
1Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, 250 College St., M5T 1R8, Canada
2Department of Psychiatry, University of Toronto, Toronto, ON, 27 King’s College Circle Toronto, Ontario M5S 1A1 Canada
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Julie A. Schneider
6Department of Neurology, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
7Rush Alzheimer’s Disease Center, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
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David A. Bennett
6Department of Neurology, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
7Rush Alzheimer’s Disease Center, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA
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Richard Mayeux
4The Department of Neurology and The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
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Philip L. De Jager
3Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
4The Department of Neurology and The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
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Giuseppe Tosto
4The Department of Neurology and The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
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  • For correspondence: gt2260@cumc.columbia.edu
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Abstract

Ethnicity impacts Alzheimer’s disease risk, especially among Caribbean-Hispanics. We report the first RNA-sequencing analysis of brain tissue from 45 Alzheimer’s disease and control Caribbean-Hispanics. Data were compared with two independent samples of non-Hispanic Caucasians (total n=729). By identifying and characterizing those genes with ancestry- and region-specific expression patterns in Alzheimer’s disease, we reveal molecular insights that may help explain epidemiological disparities in this understudied aging population.

Competing Interest Statement

Dr. Giuseppe Tosto is a Consultant for Cognition Therapeutics Inc. Leon French owns shares in Cortexyme Inc. The other authors declare no conflict of interest.

Footnotes

  • https://d2bc4766-a24a-4044-a278-1b17ae9d7538.filesusr.com/ugd/b4ee9e_aef8723281504c84a17584a34991aa85.xlsx?dn=Combined_supplementary_tables_v2.xlsx

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Posted June 10, 2020.
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The Caribbean-Hispanic Alzheimer’s Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms
Daniel Felsky, Sanjeev Sariya, Ismael Santa-Maria, Leon French, Julie A. Schneider, David A. Bennett, Richard Mayeux, Philip L. De Jager, Giuseppe Tosto
bioRxiv 2020.05.28.122234; doi: https://doi.org/10.1101/2020.05.28.122234
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The Caribbean-Hispanic Alzheimer’s Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms
Daniel Felsky, Sanjeev Sariya, Ismael Santa-Maria, Leon French, Julie A. Schneider, David A. Bennett, Richard Mayeux, Philip L. De Jager, Giuseppe Tosto
bioRxiv 2020.05.28.122234; doi: https://doi.org/10.1101/2020.05.28.122234

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