Structural basis for stereospecific inhibition of ASCT2 from rational design

Rachel-Ann A. Garibsingh; Elias Ndaru; Alisa A. Garaeva; Massimiliano Bonomi; Dirk J. Slotboom; Cristina Paulino; Christof Grewer; Avner Schlessinger

doi:10.1101/2020.05.29.124305

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Structural basis for stereospecific inhibition of ASCT2 from rational design

View ORCID ProfileRachel-Ann A. Garibsingh, View ORCID ProfileElias Ndaru, View ORCID ProfileAlisa A. Garaeva, View ORCID ProfileMassimiliano Bonomi, View ORCID ProfileDirk J. Slotboom, View ORCID ProfileCristina Paulino, View ORCID ProfileChristof Grewer, View ORCID ProfileAvner Schlessinger

doi: https://doi.org/10.1101/2020.05.29.124305

Rachel-Ann A. Garibsingh

1Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029

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Elias Ndaru

2Department of Chemistry, Binghamton University, Binghamton, NY

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Alisa A. Garaeva

3Membrane Enzymology, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, Groningen, the Netherlands

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Massimiliano Bonomi

4Structural Bioinformatics Unit, Department of Structural Biology and Chemistry; CNRS UMR 3528; C3BI, CNRS USR 3756; Institut Pasteur, Paris, France

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Dirk J. Slotboom

3Membrane Enzymology, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, Groningen, the Netherlands

6University of Groningen, Zernike Institute for Advanced Materials, Groningen, The Netherlands

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Cristina Paulino

5Structural Biology, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, Groningen, The Netherlands

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Christof Grewer

2Department of Chemistry, Binghamton University, Binghamton, NY

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Avner Schlessinger

1Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029

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For correspondence: avner.schlessinger@mssm.edu

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Structural basis for stereospecific inhibition of ASCT2 from rational design

Rachel-Ann A. Garibsingh, Elias Ndaru, Alisa A. Garaeva, Massimiliano Bonomi, Dirk J. Slotboom, Cristina Paulino, Christof Grewer, Avner Schlessinger

bioRxiv 2020.05.29.124305; doi: https://doi.org/10.1101/2020.05.29.124305

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Structural basis for stereospecific inhibition of ASCT2 from rational design

Rachel-Ann A. Garibsingh, Elias Ndaru, Alisa A. Garaeva, Massimiliano Bonomi, Dirk J. Slotboom, Cristina Paulino, Christof Grewer, Avner Schlessinger

bioRxiv 2020.05.29.124305; doi: https://doi.org/10.1101/2020.05.29.124305

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