Article Information
History
- May 30, 2020.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- PM Seidler1,
- DR Boyer1,
- MR Sawaya1,
- P Ge3,
- WS Shin2,
- MA DeTure4,
- DW Dickson4,
- L Jiang2 and
- DS Eisenberg1,*
- 1Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles CA
- 2Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles CA 90095
- 3California NanoSystem Institute, UCLA, Los Angeles, CA, USA
- 4Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
- ↵* Corresponding author; email: david{at}mbi.ucla.edu
Posted May 30, 2020.
CryoEM reveals how the small molecule EGCG binds to Alzheimer’s brain-derived tau fibrils and initiates fibril disaggregation
