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CryoEM reveals how the small molecule EGCG binds to Alzheimer’s brain-derived tau fibrils and initiates fibril disaggregation

View ORCID ProfilePM Seidler, DR Boyer, MR Sawaya, P Ge, WS Shin, MA DeTure, DW Dickson, L Jiang, DS Eisenberg
doi: https://doi.org/10.1101/2020.05.29.124537
PM Seidler
1Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles CA
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  • ORCID record for PM Seidler
DR Boyer
1Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles CA
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MR Sawaya
1Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles CA
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P Ge
3California NanoSystem Institute, UCLA, Los Angeles, CA, USA
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WS Shin
2Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles CA 90095
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MA DeTure
4Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
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DW Dickson
4Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
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L Jiang
2Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles CA 90095
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DS Eisenberg
1Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles CA
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  • For correspondence: david@mbi.ucla.edu
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Posted May 30, 2020.
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CryoEM reveals how the small molecule EGCG binds to Alzheimer’s brain-derived tau fibrils and initiates fibril disaggregation
PM Seidler, DR Boyer, MR Sawaya, P Ge, WS Shin, MA DeTure, DW Dickson, L Jiang, DS Eisenberg
bioRxiv 2020.05.29.124537; doi: https://doi.org/10.1101/2020.05.29.124537
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CryoEM reveals how the small molecule EGCG binds to Alzheimer’s brain-derived tau fibrils and initiates fibril disaggregation
PM Seidler, DR Boyer, MR Sawaya, P Ge, WS Shin, MA DeTure, DW Dickson, L Jiang, DS Eisenberg
bioRxiv 2020.05.29.124537; doi: https://doi.org/10.1101/2020.05.29.124537

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