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CryoEM reveals how the small molecule EGCG binds to Alzheimer’s brain-derived tau fibrils and initiates fibril disaggregation
View ORCID ProfilePM Seidler, DR Boyer, MR Sawaya, P Ge, WS Shin, MA DeTure, DW Dickson, L Jiang, DS Eisenberg
doi: https://doi.org/10.1101/2020.05.29.124537
PM Seidler
1Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles CA
DR Boyer
1Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles CA
MR Sawaya
1Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles CA
P Ge
3California NanoSystem Institute, UCLA, Los Angeles, CA, USA
WS Shin
2Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles CA 90095
MA DeTure
4Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
DW Dickson
4Department of Neuroscience, Mayo Clinic, Jacksonville, Florida
L Jiang
2Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles CA 90095
DS Eisenberg
1Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles CA

- Supplement[supplements/124537_file02.pdf]
Posted May 30, 2020.
CryoEM reveals how the small molecule EGCG binds to Alzheimer’s brain-derived tau fibrils and initiates fibril disaggregation
PM Seidler, DR Boyer, MR Sawaya, P Ge, WS Shin, MA DeTure, DW Dickson, L Jiang, DS Eisenberg
bioRxiv 2020.05.29.124537; doi: https://doi.org/10.1101/2020.05.29.124537
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