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LINE elements are a reservoir of regulatory potential in mammalian genomes

View ORCID ProfileMaša Roller, View ORCID ProfileEricca Stamper, View ORCID ProfileDiego Villar, View ORCID ProfileOsagie Izuogu, View ORCID ProfileFergal Martin, View ORCID ProfileAisling Redmond, Raghavendra Ramachanderan, View ORCID ProfileLouise Harewood, View ORCID ProfileDuncan T. Odom, View ORCID ProfilePaul Flicek
doi: https://doi.org/10.1101/2020.05.31.126169
Maša Roller
1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
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  • ORCID record for Maša Roller
Ericca Stamper
1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK
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Diego Villar
2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK
5Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK
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Osagie Izuogu
1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
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Fergal Martin
1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
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Aisling Redmond
2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK
6MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, CB2 0XZ, UK
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Raghavendra Ramachanderan
1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
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Louise Harewood
2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK
7Precision Medicine Centre of Excellence, Queen’s University Belfast, Belfast, BT9 7AE, UK
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Duncan T. Odom
2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK
3German Cancer Research Center (DKFZ), Division of Regulatory Genomics and Cancer Evolution, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
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  • For correspondence: d.odom@dkfz.de flicek@ebi.ac.uk
Paul Flicek
1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK
4Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
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  • For correspondence: d.odom@dkfz.de flicek@ebi.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2020.05.31.126169
History 
  • May 31, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Maša Roller1,*,
  2. Ericca Stamper1,2,*,
  3. Diego Villar2,5,
  4. Osagie Izuogu1,
  5. Fergal Martin1,
  6. Aisling Redmond2,6,
  7. Raghavendra Ramachanderan1,
  8. Louise Harewood2,7,
  9. Duncan T. Odom2,3,† and
  10. Paul Flicek1,2,4,†,‡
  1. 1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
  2. 2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK
  3. 3German Cancer Research Center (DKFZ), Division of Regulatory Genomics and Cancer Evolution, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
  4. 4Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
  5. 5Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK
  6. 6MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, CB2 0XZ, UK
  7. 7Precision Medicine Centre of Excellence, Queen’s University Belfast, Belfast, BT9 7AE, UK
  1. ↵†Correspondence: d.odom{at}dkfz.de (D.T.O.), flicek{at}ebi.ac.uk (P.F.)
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LINE elements are a reservoir of regulatory potential in mammalian genomes
Maša Roller, Ericca Stamper, Diego Villar, Osagie Izuogu, Fergal Martin, Aisling Redmond, Raghavendra Ramachanderan, Louise Harewood, Duncan T. Odom, Paul Flicek
bioRxiv 2020.05.31.126169; doi: https://doi.org/10.1101/2020.05.31.126169
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LINE elements are a reservoir of regulatory potential in mammalian genomes
Maša Roller, Ericca Stamper, Diego Villar, Osagie Izuogu, Fergal Martin, Aisling Redmond, Raghavendra Ramachanderan, Louise Harewood, Duncan T. Odom, Paul Flicek
bioRxiv 2020.05.31.126169; doi: https://doi.org/10.1101/2020.05.31.126169

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