LINE elements are a reservoir of regulatory potential in mammalian genomes

Maša Roller; Ericca Stamper; Diego Villar; Osagie Izuogu; Fergal Martin; Aisling Redmond; Raghavendra Ramachanderan; Louise Harewood; Duncan T. Odom; Paul Flicek

doi:10.1101/2020.05.31.126169

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LINE elements are a reservoir of regulatory potential in mammalian genomes

View ORCID ProfileMaša Roller, View ORCID ProfileEricca Stamper, View ORCID ProfileDiego Villar, View ORCID ProfileOsagie Izuogu, View ORCID ProfileFergal Martin, View ORCID ProfileAisling Redmond, Raghavendra Ramachanderan, View ORCID ProfileLouise Harewood, View ORCID ProfileDuncan T. Odom, View ORCID ProfilePaul Flicek

doi: https://doi.org/10.1101/2020.05.31.126169

Maša Roller

1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

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Ericca Stamper

1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK

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Diego Villar

2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK

5Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK

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Osagie Izuogu

1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

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Fergal Martin

1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

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Aisling Redmond

2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK

6MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, CB2 0XZ, UK

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Raghavendra Ramachanderan

1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

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Louise Harewood

2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK

7Precision Medicine Centre of Excellence, Queen’s University Belfast, Belfast, BT9 7AE, UK

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Duncan T. Odom

2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK

3German Cancer Research Center (DKFZ), Division of Regulatory Genomics and Cancer Evolution, Im Neuenheimer Feld 280, Heidelberg 69120, Germany

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For correspondence: d.odom@dkfz.de flicek@ebi.ac.uk

Paul Flicek

1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

2Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK

4Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

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For correspondence: d.odom@dkfz.de flicek@ebi.ac.uk

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LINE elements are a reservoir of regulatory potential in mammalian genomes

Maša Roller, Ericca Stamper, Diego Villar, Osagie Izuogu, Fergal Martin, Aisling Redmond, Raghavendra Ramachanderan, Louise Harewood, Duncan T. Odom, Paul Flicek

bioRxiv 2020.05.31.126169; doi: https://doi.org/10.1101/2020.05.31.126169

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LINE elements are a reservoir of regulatory potential in mammalian genomes

Maša Roller, Ericca Stamper, Diego Villar, Osagie Izuogu, Fergal Martin, Aisling Redmond, Raghavendra Ramachanderan, Louise Harewood, Duncan T. Odom, Paul Flicek

bioRxiv 2020.05.31.126169; doi: https://doi.org/10.1101/2020.05.31.126169

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