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Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements

View ORCID ProfileAntimo Buonocore, Matthias P. Baumann, View ORCID ProfileZiad M. Hafed
doi: https://doi.org/10.1101/2020.05.31.126359
Antimo Buonocore
1Werner Reichardt Centre for Integrative Neuroscience, Tübingen University, Tübingen, BW, 72076, Germany
2Hertie Institute for Clinical Brain Research, Tübingen University, Tübingen, BW, 72076, Germany
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  • For correspondence: antimo.buonocore@cin.uni-tuebingen.de
Matthias P. Baumann
1Werner Reichardt Centre for Integrative Neuroscience, Tübingen University, Tübingen, BW, 72076, Germany
2Hertie Institute for Clinical Brain Research, Tübingen University, Tübingen, BW, 72076, Germany
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Ziad M. Hafed
1Werner Reichardt Centre for Integrative Neuroscience, Tübingen University, Tübingen, BW, 72076, Germany
2Hertie Institute for Clinical Brain Research, Tübingen University, Tübingen, BW, 72076, Germany
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Abstract

At any moment in time, new information is sampled from the environment and interacts with ongoing brain state. Often, such interaction takes place within individual circuits that are capable of both mediating the internally ongoing plan as well as representing exogenous sensory events. Here we investigated how sensory-driven neural activity can be integrated, very often in the same neuron types, into ongoing oculomotor commands for saccades. Despite the ballistic nature of saccades, visually-induced action potentials in the superior colliculus (SC), a structure known to drive eye movements, not only occurred intra-saccadically, but they were also associated with highly predictable modifications of the ongoing eye movements. Such modifications were also possible by peri-saccadically injecting single, double, or triple electrical microstimulation pulses into the SC. Our results suggest instantaneous readout of the SC map during movement generation, irrespective of activity source, and explain a significant component of kinematic variability of motor outputs.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted June 01, 2020.
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Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements
Antimo Buonocore, Matthias P. Baumann, Ziad M. Hafed
bioRxiv 2020.05.31.126359; doi: https://doi.org/10.1101/2020.05.31.126359
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Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements
Antimo Buonocore, Matthias P. Baumann, Ziad M. Hafed
bioRxiv 2020.05.31.126359; doi: https://doi.org/10.1101/2020.05.31.126359

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