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Dense Computer Replica of Cortical Microcircuits Unravels Cellular Underpinnings of Auditory Surprise Response

View ORCID ProfileOren Amsalem, James King, Michael Reimann, Srikanth Ramaswamy, Eilif Muller, Henry Markram, View ORCID ProfileIsrael Nelken, View ORCID ProfileIdan Segev
doi: https://doi.org/10.1101/2020.05.31.126466
Oren Amsalem
1Department of Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel
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  • For correspondence: oren.amsalem1@mail.huji.ac.il
James King
2Blue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland
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Michael Reimann
2Blue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland
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Srikanth Ramaswamy
2Blue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland
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Eilif Muller
2Blue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland
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Henry Markram
2Blue Brain Project, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland
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Israel Nelken
1Department of Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel
3The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
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Idan Segev
1Department of Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel
3The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
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Abstract

The nervous system is notorious for its strong response evoked by a surprising sensory input, but the biophysical and anatomical underpinnings of this phenomenon are only partially understood. Here we utilized in-silico experiments of a biologically-detailed model of a neocortical microcircuit to study stimulus specific adaptation (SSA) in the auditory cortex, whereby the neuronal response adapts significantly for a repeated (“expected”) tone but not for a rare (“surprise”) tone. SSA experiments were mimicked by stimulating tonotopically-mapped thalamo-cortical afferents projecting to the microcircuit; the activity of these afferents was modeled based on our in-vivo recordings from individual thalamic neurons. The modeled microcircuit expressed naturally many experimentally-observed properties of SSA, suggesting that SSA is a general property of neocortical microcircuits. By systematically modulating circuit parameters, we found that key features of SSA depended on synergistic effects of synaptic depression, spike frequency adaptation and recurrent network connectivity. The relative contribution of each of these mechanisms in shaping SSA was explored, additional SSA-related experimental results were explained and new experiments for further studying SSA were suggested.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted June 01, 2020.
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Dense Computer Replica of Cortical Microcircuits Unravels Cellular Underpinnings of Auditory Surprise Response
Oren Amsalem, James King, Michael Reimann, Srikanth Ramaswamy, Eilif Muller, Henry Markram, Israel Nelken, Idan Segev
bioRxiv 2020.05.31.126466; doi: https://doi.org/10.1101/2020.05.31.126466
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Dense Computer Replica of Cortical Microcircuits Unravels Cellular Underpinnings of Auditory Surprise Response
Oren Amsalem, James King, Michael Reimann, Srikanth Ramaswamy, Eilif Muller, Henry Markram, Israel Nelken, Idan Segev
bioRxiv 2020.05.31.126466; doi: https://doi.org/10.1101/2020.05.31.126466

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