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SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells

View ORCID ProfileCharlotte Martinat, Arthur Cormier, Joёlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Si’Ana A. Coggins, View ORCID ProfileJulian Buchrieser, Mirjana Persaud, Felipe Diaz-Griffero, View ORCID ProfileLucile Espert, View ORCID ProfileGuillaume Bossis, View ORCID ProfilePascale Lesage, View ORCID ProfileOlivier Schwartz, View ORCID ProfileBaek Kim, View ORCID ProfileFlorence Margottin-Goguet, Ali Saïb, View ORCID ProfileAlessia Zamborlini
doi: https://doi.org/10.1101/2020.06.04.133439
Charlotte Martinat
1INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France
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  • ORCID record for Charlotte Martinat
Arthur Cormier
1INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France
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Joёlle Tobaly-Tapiero
1INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France
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Noé Palmic
1INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France
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Nicoletta Casartelli
2Institut Pasteur, Virus and Immunity Unit, CNRS-UMR3569, Paris, France
3Vaccine Research Institute, Créteil, France
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Si’Ana A. Coggins
4Emory School of Medicine, Atlanta, USA
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Julian Buchrieser
2Institut Pasteur, Virus and Immunity Unit, CNRS-UMR3569, Paris, France
3Vaccine Research Institute, Créteil, France
5James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK
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Mirjana Persaud
6Albert Einstein College of Medicine, Microbiology and Immunology, Bronx, NY, 10461, USA
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Felipe Diaz-Griffero
6Albert Einstein College of Medicine, Microbiology and Immunology, Bronx, NY, 10461, USA
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Lucile Espert
7IRIM, University of Montpellier, UMR 9004 CNRS, 34293 Montpellier, France
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  • ORCID record for Lucile Espert
Guillaume Bossis
8IGMM, Univ Montpellier, CNRS, Montpellier, France
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Pascale Lesage
1INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France
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Olivier Schwartz
2Institut Pasteur, Virus and Immunity Unit, CNRS-UMR3569, Paris, France
3Vaccine Research Institute, Créteil, France
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Baek Kim
4Emory School of Medicine, Atlanta, USA
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Florence Margottin-Goguet
9Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 PARIS, France
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  • ORCID record for Florence Margottin-Goguet
Ali Saïb
1INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France
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Alessia Zamborlini
1INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France
10institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, France
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  • For correspondence: alessia.zamborlini@universite-paris-saclay.fr
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Article Information

doi 
https://doi.org/10.1101/2020.06.04.133439
History 
  • June 5, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Charlotte Martinat1,§,
  2. Arthur Cormier1,§,
  3. Joёlle Tobaly-Tapiero1,
  4. Noé Palmic1,
  5. Nicoletta Casartelli2,3,
  6. Si’Ana A. Coggins4,
  7. Julian Buchrieser2,3,5,
  8. Mirjana Persaud6,
  9. Felipe Diaz-Griffero6,
  10. Lucile Espert7,
  11. Guillaume Bossis8,
  12. Pascale Lesage1,
  13. Olivier Schwartz2,3,
  14. Baek Kim4,
  15. Florence Margottin-Goguet9,
  16. Ali Saïb1 and
  17. Alessia Zamborlini1,10,*
  1. 1INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France
  2. 2Institut Pasteur, Virus and Immunity Unit, CNRS-UMR3569, Paris, France
  3. 3Vaccine Research Institute, Créteil, France
  4. 4Emory School of Medicine, Atlanta, USA
  5. 5James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK
  6. 6Albert Einstein College of Medicine, Microbiology and Immunology, Bronx, NY, 10461, USA
  7. 7IRIM, University of Montpellier, UMR 9004 CNRS, 34293 Montpellier, France
  8. 8IGMM, Univ Montpellier, CNRS, Montpellier, France
  9. 9Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 PARIS, France
  10. 10institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, France
  1. ↵#Correspondence and requests for materials should be addressed to A. Zamborlini: alessia.zamborlini{at}universite-paris-saclay.fr
  1. ↵§ These authors contributed equally: Charlotte Martinat, Arthur Cormier.

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SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
Charlotte Martinat, Arthur Cormier, Joёlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Si’Ana A. Coggins, Julian Buchrieser, Mirjana Persaud, Felipe Diaz-Griffero, Lucile Espert, Guillaume Bossis, Pascale Lesage, Olivier Schwartz, Baek Kim, Florence Margottin-Goguet, Ali Saïb, Alessia Zamborlini
bioRxiv 2020.06.04.133439; doi: https://doi.org/10.1101/2020.06.04.133439
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SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
Charlotte Martinat, Arthur Cormier, Joёlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Si’Ana A. Coggins, Julian Buchrieser, Mirjana Persaud, Felipe Diaz-Griffero, Lucile Espert, Guillaume Bossis, Pascale Lesage, Olivier Schwartz, Baek Kim, Florence Margottin-Goguet, Ali Saïb, Alessia Zamborlini
bioRxiv 2020.06.04.133439; doi: https://doi.org/10.1101/2020.06.04.133439

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