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RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site
Katarzyna Z Haza, View ORCID ProfileHeather L Martin, Ajinkya Rao, View ORCID ProfileAmy L Turner, Sophie E Saunders, Britta Petersen, View ORCID ProfileChristian Tiede, Kevin Tipping, Anna A Tang, Modupe Ajayi, Thomas Taylor, Keri M Fishwick, Thomas L Adams, View ORCID ProfileThembaninkosi G. Gaule, Chi H Trinh, Matthew Johnson, View ORCID ProfileAlexander L Breeze, View ORCID ProfileThomas A Edwards, View ORCID ProfileMichael J McPherson, View ORCID ProfileDarren C Tomlinson
doi: https://doi.org/10.1101/2020.06.04.133728
Katarzyna Z Haza
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Heather L Martin
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Ajinkya Rao
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Amy L Turner
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Sophie E Saunders
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Britta Petersen
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Christian Tiede
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Kevin Tipping
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Anna A Tang
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Modupe Ajayi
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Thomas Taylor
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Keri M Fishwick
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Thomas L Adams
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Thembaninkosi G. Gaule
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Chi H Trinh
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Matthew Johnson
2Avacta Life Sciences, Wetherby, UK
Alexander L Breeze
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Thomas A Edwards
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Michael J McPherson
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Darren C Tomlinson
1School of Molecular and Cellular Biology, Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, UK
Posted June 05, 2020.
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site
Katarzyna Z Haza, Heather L Martin, Ajinkya Rao, Amy L Turner, Sophie E Saunders, Britta Petersen, Christian Tiede, Kevin Tipping, Anna A Tang, Modupe Ajayi, Thomas Taylor, Keri M Fishwick, Thomas L Adams, Thembaninkosi G. Gaule, Chi H Trinh, Matthew Johnson, Alexander L Breeze, Thomas A Edwards, Michael J McPherson, Darren C Tomlinson
bioRxiv 2020.06.04.133728; doi: https://doi.org/10.1101/2020.06.04.133728
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site
Katarzyna Z Haza, Heather L Martin, Ajinkya Rao, Amy L Turner, Sophie E Saunders, Britta Petersen, Christian Tiede, Kevin Tipping, Anna A Tang, Modupe Ajayi, Thomas Taylor, Keri M Fishwick, Thomas L Adams, Thembaninkosi G. Gaule, Chi H Trinh, Matthew Johnson, Alexander L Breeze, Thomas A Edwards, Michael J McPherson, Darren C Tomlinson
bioRxiv 2020.06.04.133728; doi: https://doi.org/10.1101/2020.06.04.133728
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