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Locus coeruleus spiking differently correlates with somatosensory cortex activity and pupil diameter

Hongdian Yang, Bilal A. Bari, Jeremiah Y. Cohen, View ORCID ProfileDaniel H. O’Connor
doi: https://doi.org/10.1101/2020.06.04.134676
Hongdian Yang
1Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA 92521, USA
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  • For correspondence: hongdian@ucr.edu dan.oconnor@jhmi.edu
Bilal A. Bari
2Department of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA
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Jeremiah Y. Cohen
2Department of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA
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Daniel H. O’Connor
2Department of Neuroscience, Brain Science Institute, and Kavli Neuroscience Discovery Institute, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA
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  • ORCID record for Daniel H. O’Connor
  • For correspondence: hongdian@ucr.edu dan.oconnor@jhmi.edu
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ABSTRACT

We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1 and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 04, 2020.
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Locus coeruleus spiking differently correlates with somatosensory cortex activity and pupil diameter
Hongdian Yang, Bilal A. Bari, Jeremiah Y. Cohen, Daniel H. O’Connor
bioRxiv 2020.06.04.134676; doi: https://doi.org/10.1101/2020.06.04.134676
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Locus coeruleus spiking differently correlates with somatosensory cortex activity and pupil diameter
Hongdian Yang, Bilal A. Bari, Jeremiah Y. Cohen, Daniel H. O’Connor
bioRxiv 2020.06.04.134676; doi: https://doi.org/10.1101/2020.06.04.134676

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