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An OpenData portal to share COVID-19 drug repurposing data in real time

Kyle R. Brimacombe, Tongan Zhao, View ORCID ProfileRichard T. Eastman, Xin Hu, Ke Wang, Mark Backus, Bolormaa Baljinnyam, Catherine Z. Chen, Lu Chen, Tara Eicher, Marc Ferrer, Ying Fu, Kirill Gorshkov, Hui Guo, Quinlin M. Hanson, Zina Itkin, Stephen C. Kales, Carleen Klumpp-Thomas, Emily M. Lee, Sam Michael, Tim Mierzwa, Andrew Patt, Manisha Pradhan, Alex Renn, Paul Shinn, Jonathan H. Shrimp, Amit Viraktamath, Kelli M. Wilson, Miao Xu, Alexey V. Zakharov, Wei Zhu, Wei Zheng, Anton Simeonov, Ewy A. Mathé, Donald C. Lo, View ORCID ProfileMatthew D. Hall, Min Shen
doi: https://doi.org/10.1101/2020.06.04.135046
Kyle R. Brimacombe
1National Center for Advancing Translational Sciences, National Institutes of Health
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Tongan Zhao
1National Center for Advancing Translational Sciences, National Institutes of Health
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Richard T. Eastman
1National Center for Advancing Translational Sciences, National Institutes of Health
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Xin Hu
1National Center for Advancing Translational Sciences, National Institutes of Health
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Ke Wang
1National Center for Advancing Translational Sciences, National Institutes of Health
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Mark Backus
1National Center for Advancing Translational Sciences, National Institutes of Health
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Bolormaa Baljinnyam
1National Center for Advancing Translational Sciences, National Institutes of Health
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Catherine Z. Chen
1National Center for Advancing Translational Sciences, National Institutes of Health
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Lu Chen
1National Center for Advancing Translational Sciences, National Institutes of Health
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Tara Eicher
1National Center for Advancing Translational Sciences, National Institutes of Health
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Marc Ferrer
1National Center for Advancing Translational Sciences, National Institutes of Health
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Ying Fu
1National Center for Advancing Translational Sciences, National Institutes of Health
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Kirill Gorshkov
1National Center for Advancing Translational Sciences, National Institutes of Health
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Hui Guo
1National Center for Advancing Translational Sciences, National Institutes of Health
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Quinlin M. Hanson
1National Center for Advancing Translational Sciences, National Institutes of Health
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Zina Itkin
1National Center for Advancing Translational Sciences, National Institutes of Health
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Stephen C. Kales
1National Center for Advancing Translational Sciences, National Institutes of Health
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Carleen Klumpp-Thomas
1National Center for Advancing Translational Sciences, National Institutes of Health
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Emily M. Lee
1National Center for Advancing Translational Sciences, National Institutes of Health
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Sam Michael
1National Center for Advancing Translational Sciences, National Institutes of Health
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Tim Mierzwa
1National Center for Advancing Translational Sciences, National Institutes of Health
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Andrew Patt
1National Center for Advancing Translational Sciences, National Institutes of Health
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Manisha Pradhan
1National Center for Advancing Translational Sciences, National Institutes of Health
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Alex Renn
1National Center for Advancing Translational Sciences, National Institutes of Health
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Paul Shinn
1National Center for Advancing Translational Sciences, National Institutes of Health
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Jonathan H. Shrimp
1National Center for Advancing Translational Sciences, National Institutes of Health
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Amit Viraktamath
1National Center for Advancing Translational Sciences, National Institutes of Health
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Kelli M. Wilson
1National Center for Advancing Translational Sciences, National Institutes of Health
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Miao Xu
1National Center for Advancing Translational Sciences, National Institutes of Health
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Alexey V. Zakharov
1National Center for Advancing Translational Sciences, National Institutes of Health
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Wei Zhu
1National Center for Advancing Translational Sciences, National Institutes of Health
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Wei Zheng
1National Center for Advancing Translational Sciences, National Institutes of Health
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Anton Simeonov
1National Center for Advancing Translational Sciences, National Institutes of Health
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Ewy A. Mathé
1National Center for Advancing Translational Sciences, National Institutes of Health
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Donald C. Lo
1National Center for Advancing Translational Sciences, National Institutes of Health
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Matthew D. Hall
1National Center for Advancing Translational Sciences, National Institutes of Health
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  • For correspondence: hallma@mail.nih.gov shenmin@mail.nih.gov
Min Shen
1National Center for Advancing Translational Sciences, National Institutes of Health
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  • For correspondence: hallma@mail.nih.gov shenmin@mail.nih.gov
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Abstract

The National Center for Advancing Translational Sciences (NCATS) has developed an online open science data portal for its COVID-19 drug repurposing campaign – named OpenData – with the goal of making data across a range of SARS-CoV-2 related assays available in real-time. The assays developed cover a wide spectrum of the SARS-CoV-2 life cycle, including both viral and human (host) targets. In total, over 10,000 compounds are being tested in full concentration-response ranges from across multiple annotated small molecule libraries, including approved drug, repurposing candidates and experimental therapeutics designed to modulate a wide range of cellular targets. The goal is to support research scientists, clinical investigators and public health officials through open data sharing and analysis tools to expedite the development of SARS-CoV-2 interventions, and to prioritize promising compounds and repurposed drugs for further development in treating COVID-19.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://opendata.ncats.nih.gov/covid19/

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted June 05, 2020.
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An OpenData portal to share COVID-19 drug repurposing data in real time
Kyle R. Brimacombe, Tongan Zhao, Richard T. Eastman, Xin Hu, Ke Wang, Mark Backus, Bolormaa Baljinnyam, Catherine Z. Chen, Lu Chen, Tara Eicher, Marc Ferrer, Ying Fu, Kirill Gorshkov, Hui Guo, Quinlin M. Hanson, Zina Itkin, Stephen C. Kales, Carleen Klumpp-Thomas, Emily M. Lee, Sam Michael, Tim Mierzwa, Andrew Patt, Manisha Pradhan, Alex Renn, Paul Shinn, Jonathan H. Shrimp, Amit Viraktamath, Kelli M. Wilson, Miao Xu, Alexey V. Zakharov, Wei Zhu, Wei Zheng, Anton Simeonov, Ewy A. Mathé, Donald C. Lo, Matthew D. Hall, Min Shen
bioRxiv 2020.06.04.135046; doi: https://doi.org/10.1101/2020.06.04.135046
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An OpenData portal to share COVID-19 drug repurposing data in real time
Kyle R. Brimacombe, Tongan Zhao, Richard T. Eastman, Xin Hu, Ke Wang, Mark Backus, Bolormaa Baljinnyam, Catherine Z. Chen, Lu Chen, Tara Eicher, Marc Ferrer, Ying Fu, Kirill Gorshkov, Hui Guo, Quinlin M. Hanson, Zina Itkin, Stephen C. Kales, Carleen Klumpp-Thomas, Emily M. Lee, Sam Michael, Tim Mierzwa, Andrew Patt, Manisha Pradhan, Alex Renn, Paul Shinn, Jonathan H. Shrimp, Amit Viraktamath, Kelli M. Wilson, Miao Xu, Alexey V. Zakharov, Wei Zhu, Wei Zheng, Anton Simeonov, Ewy A. Mathé, Donald C. Lo, Matthew D. Hall, Min Shen
bioRxiv 2020.06.04.135046; doi: https://doi.org/10.1101/2020.06.04.135046

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