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Anesthetics uniquely decorrelate hippocampal network activity, alter spine dynamics and affect memory consolidation

Wei Yang, View ORCID ProfileMattia Chini, View ORCID ProfileJastyn A. Pöpplau, View ORCID ProfileAndrey Formozov, Patrick Piechocinski, Cynthia Rais, View ORCID ProfileFabio Morellini, View ORCID ProfileOlaf Sporns, View ORCID ProfileIleana L. Hanganu-Opatz, View ORCID ProfileJ. Simon Wiegert
doi: https://doi.org/10.1101/2020.06.05.135905
Wei Yang
1Research Group Synaptic Wiring and Information Processing, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
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Mattia Chini
2Developmental Neurophysiology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
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  • ORCID record for Mattia Chini
Jastyn A. Pöpplau
2Developmental Neurophysiology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
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Andrey Formozov
1Research Group Synaptic Wiring and Information Processing, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
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Patrick Piechocinski
1Research Group Synaptic Wiring and Information Processing, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
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Cynthia Rais
1Research Group Synaptic Wiring and Information Processing, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
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Fabio Morellini
3Research Group Behavioral Biology, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
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Olaf Sporns
4Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA
5Indiana University Network Science Institute, Indiana University, Bloomington, Indiana, USA
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Ileana L. Hanganu-Opatz
2Developmental Neurophysiology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
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  • ORCID record for Ileana L. Hanganu-Opatz
J. Simon Wiegert
1Research Group Synaptic Wiring and Information Processing, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
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  • For correspondence: simon.wiegert@zmnh.uni-hamburg.de
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SUMMARY

General anesthesia is characterized by reversible loss of consciousness accompanied by transient amnesia. Yet, long-term memory impairment is an undesirable side-effect. How different types of general anesthetics (GAs) affect the hippocampus, a brain region central to memory formation and consolidation, is poorly understood. Using extracellular recordings, chronic 2-photon imaging and behavioral analysis, we monitor the effects of isoflurane (Iso), medetomidine/midazolam/fentanyl (MMF), and ketamine/xylazine (Keta/Xyl) on network activity and structural spine dynamics in the hippocampal CA1 area of adult mice. GAs robustly reduced spiking activity, decorrelated cellular ensembles, albeit with distinct activity signatures, and altered spine dynamics. Iso anesthesia most closely resembled wakefulness, and network alterations recovered more readily than with Keta/Xyl and MMF. Correspondingly, memory consolidation was impaired after exposure to Keta/Xyl and MMF, but not Iso. Thus, different anesthetics distinctly alter hippocampal network dynamics, synaptic connectivity, and memory consolidation, with implications for GA strategy appraisal in animal research and clinical settings.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 06, 2020.
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Anesthetics uniquely decorrelate hippocampal network activity, alter spine dynamics and affect memory consolidation
Wei Yang, Mattia Chini, Jastyn A. Pöpplau, Andrey Formozov, Patrick Piechocinski, Cynthia Rais, Fabio Morellini, Olaf Sporns, Ileana L. Hanganu-Opatz, J. Simon Wiegert
bioRxiv 2020.06.05.135905; doi: https://doi.org/10.1101/2020.06.05.135905
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Anesthetics uniquely decorrelate hippocampal network activity, alter spine dynamics and affect memory consolidation
Wei Yang, Mattia Chini, Jastyn A. Pöpplau, Andrey Formozov, Patrick Piechocinski, Cynthia Rais, Fabio Morellini, Olaf Sporns, Ileana L. Hanganu-Opatz, J. Simon Wiegert
bioRxiv 2020.06.05.135905; doi: https://doi.org/10.1101/2020.06.05.135905

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