Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Task-dependent mixed selectivity in the subiculum

View ORCID ProfileDebora Ledergerber, View ORCID ProfileClaudia Battistin, View ORCID ProfileJan Sigurd Blackstad, View ORCID ProfileRichard J. Gardner, View ORCID ProfileMenno P. Witter, May-Britt Moser, View ORCID ProfileYasser Roudi, View ORCID ProfileEdvard I. Moser
doi: https://doi.org/10.1101/2020.06.06.129221
Debora Ledergerber
Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Debora Ledergerber
  • For correspondence: dlederger@ethz.ch yasser.roudi@ntnu.no edvard.moser@ntnu.no
Claudia Battistin
Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Claudia Battistin
Jan Sigurd Blackstad
Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jan Sigurd Blackstad
Richard J. Gardner
Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Richard J. Gardner
Menno P. Witter
Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Menno P. Witter
May-Britt Moser
Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yasser Roudi
Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Yasser Roudi
  • For correspondence: dlederger@ethz.ch yasser.roudi@ntnu.no edvard.moser@ntnu.no
Edvard I. Moser
Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Edvard I. Moser
  • For correspondence: dlederger@ethz.ch yasser.roudi@ntnu.no edvard.moser@ntnu.no
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Summary

CA1 and subiculum (SUB) connect the hippocampus to numerous output regions. Cells in both areas have place-specific firing fields, although they are more dispersed in SUB. Weak responses to head direction and running speed have been reported in both regions. However, how such information is encoded in CA1 and SUB, and the resulting impact on downstream targets, is poorly understood. Here we estimate the tuning of simultaneously recorded CA1 and SUB cells to position, head direction, and speed. Individual neurons respond conjunctively to these covariates in both regions but the degree of mixed representation is stronger in SUB, and more so during goal-directed spatial navigation than free foraging. Each navigational variable could be decoded with higher precision, from a similar number of neurons, in SUB than CA1. The findings point to a possible contribution of mixed-selective coding in SUB to efficient transmission of hippocampal representations to widespread brain regions.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Lead contact: Edvard I. Moser, edvard.moser{at}ntnu.no

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted June 08, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Task-dependent mixed selectivity in the subiculum
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Task-dependent mixed selectivity in the subiculum
Debora Ledergerber, Claudia Battistin, Jan Sigurd Blackstad, Richard J. Gardner, Menno P. Witter, May-Britt Moser, Yasser Roudi, Edvard I. Moser
bioRxiv 2020.06.06.129221; doi: https://doi.org/10.1101/2020.06.06.129221
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Task-dependent mixed selectivity in the subiculum
Debora Ledergerber, Claudia Battistin, Jan Sigurd Blackstad, Richard J. Gardner, Menno P. Witter, May-Britt Moser, Yasser Roudi, Edvard I. Moser
bioRxiv 2020.06.06.129221; doi: https://doi.org/10.1101/2020.06.06.129221

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (3477)
  • Biochemistry (7316)
  • Bioengineering (5294)
  • Bioinformatics (20189)
  • Biophysics (9972)
  • Cancer Biology (7697)
  • Cell Biology (11243)
  • Clinical Trials (138)
  • Developmental Biology (6416)
  • Ecology (9911)
  • Epidemiology (2065)
  • Evolutionary Biology (13271)
  • Genetics (9347)
  • Genomics (12544)
  • Immunology (7667)
  • Microbiology (18928)
  • Molecular Biology (7415)
  • Neuroscience (40870)
  • Paleontology (298)
  • Pathology (1226)
  • Pharmacology and Toxicology (2125)
  • Physiology (3138)
  • Plant Biology (6836)
  • Scientific Communication and Education (1268)
  • Synthetic Biology (1891)
  • Systems Biology (5295)
  • Zoology (1083)