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A genomic amplification affecting a carboxylesterase gene cluster confers organophosphate resistance in the mosquito Aedes aegypti: from genomic characterization to high-throughput field detection

Julien Cattel, Chloé Haberkorn, Fréderic Laporte, Thierry Gaude, Tristan Cumer, Julien Renaud, Ian W. Sutherland, Jeffrey C. Hertz, Jean-Marc Bonneville, Victor Arnaud, Camille Noûs, Bénédicte Fustec, Sébastien Boyer, Sébastien Marcombe, Jean-Philippe David
doi: https://doi.org/10.1101/2020.06.08.139741
Julien Cattel
1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France
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  • For correspondence: juliencattel@gmail.com
Chloé Haberkorn
1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France
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Fréderic Laporte
1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France
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Thierry Gaude
1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France
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Tristan Cumer
1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France
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Julien Renaud
1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France
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Ian W. Sutherland
2United States Navy Entomology. Center of Excellence, NAS Jacksonville, Florida, United States of America
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Jeffrey C. Hertz
3US Naval Medical Research Unit No. 2, Singapore
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Jean-Marc Bonneville
1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France
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Victor Arnaud
1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France
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Camille Noûs
4Laboratoire Cogitamus, 1 ¾ rue Descartes, 75005 Paris, France
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Bénédicte Fustec
5Department of Microbiology, Khon Kaen University, Khon Kaen, Thailand
6Institut de Recherche pour le Développement, UMR IRD 224-CNRS 5290-Université Montpellier. 911, avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, FRANCE
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Sébastien Boyer
7Medical and Veterinary Entomology, Institut Pasteur du Cambodge, P.O Box. 983 Phnom Penh, Cambodia
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Sébastien Marcombe
8Medical Entomology and Vector-Borne Disease Laboratory, Institut Pasteur du Laos, Vientiane, Laos
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Jean-Philippe David
1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France
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Article Information

doi 
https://doi.org/10.1101/2020.06.08.139741
History 
  • November 4, 2020.

Article Versions

  • Version 1 (June 8, 2020 - 22:27).
  • Version 2 (September 25, 2020 - 01:14).
  • Version 3 (October 19, 2020 - 19:35).
  • You are viewing Version 4, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Julien Cattel1,§,#,
  2. Chloé Haberkorn1,
  3. Fréderic Laporte1,
  4. Thierry Gaude1,
  5. Tristan Cumer1,
  6. Julien Renaud1,
  7. Ian W. Sutherland2,
  8. Jeffrey C. Hertz3,
  9. Jean-Marc Bonneville1,
  10. Victor Arnaud1,
  11. Camille Noûs4,
  12. Bénédicte Fustec5,6,
  13. Sébastien Boyer7,
  14. Sébastien Marcombe8 and
  15. Jean-Philippe David1
  1. 1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France
  2. 2United States Navy Entomology. Center of Excellence, NAS Jacksonville, Florida, United States of America
  3. 3US Naval Medical Research Unit No. 2, Singapore
  4. 4Laboratoire Cogitamus, 1 ¾ rue Descartes, 75005 Paris, France
  5. 5Department of Microbiology, Khon Kaen University, Khon Kaen, Thailand
  6. 6Institut de Recherche pour le Développement, UMR IRD 224-CNRS 5290-Université Montpellier. 911, avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, FRANCE
  7. 7Medical and Veterinary Entomology, Institut Pasteur du Cambodge, P.O Box. 983 Phnom Penh, Cambodia
  8. 8Medical Entomology and Vector-Borne Disease Laboratory, Institut Pasteur du Laos, Vientiane, Laos
  1. ↵#Correspondence: email juliencattel{at}gmail.com
  • ↵§ Symbiosis Technologies for Insect Control (SymbioTIC). Plateforme de Recherche Cyroi, 2 rue Maxime Rivière, 97490 Ste Clotilde, France

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A genomic amplification affecting a carboxylesterase gene cluster confers organophosphate resistance in the mosquito Aedes aegypti: from genomic characterization to high-throughput field detection
Julien Cattel, Chloé Haberkorn, Fréderic Laporte, Thierry Gaude, Tristan Cumer, Julien Renaud, Ian W. Sutherland, Jeffrey C. Hertz, Jean-Marc Bonneville, Victor Arnaud, Camille Noûs, Bénédicte Fustec, Sébastien Boyer, Sébastien Marcombe, Jean-Philippe David
bioRxiv 2020.06.08.139741; doi: https://doi.org/10.1101/2020.06.08.139741
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A genomic amplification affecting a carboxylesterase gene cluster confers organophosphate resistance in the mosquito Aedes aegypti: from genomic characterization to high-throughput field detection
Julien Cattel, Chloé Haberkorn, Fréderic Laporte, Thierry Gaude, Tristan Cumer, Julien Renaud, Ian W. Sutherland, Jeffrey C. Hertz, Jean-Marc Bonneville, Victor Arnaud, Camille Noûs, Bénédicte Fustec, Sébastien Boyer, Sébastien Marcombe, Jean-Philippe David
bioRxiv 2020.06.08.139741; doi: https://doi.org/10.1101/2020.06.08.139741

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