A genomic amplification affecting a carboxylesterase gene cluster confers organophosphate resistance in the mosquito Aedes aegypti: from genomic characterization to high-throughput field detection

Julien Cattel; Chloé Haberkorn; Fréderic Laporte; Thierry Gaude; Tristan Cumer; Julien Renaud; Ian W. Sutherland; Jeffrey C. Hertz; Jean-Marc Bonneville; Victor Arnaud; Camille Noûs; Bénédicte Fustec; Sébastien Boyer; Sébastien Marcombe; Jean-Philippe David

doi:10.1101/2020.06.08.139741

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A genomic amplification affecting a carboxylesterase gene cluster confers organophosphate resistance in the mosquito Aedes aegypti: from genomic characterization to high-throughput field detection

Julien Cattel, Chloé Haberkorn, Fréderic Laporte, Thierry Gaude, Tristan Cumer, Julien Renaud, Ian W. Sutherland, Jeffrey C. Hertz, Jean-Marc Bonneville, Victor Arnaud, Camille Noûs, Bénédicte Fustec, Sébastien Boyer, Sébastien Marcombe, Jean-Philippe David

doi: https://doi.org/10.1101/2020.06.08.139741

Julien Cattel

1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France

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For correspondence: juliencattel@gmail.com

Chloé Haberkorn

1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France

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Fréderic Laporte

1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France

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Thierry Gaude

1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France

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Tristan Cumer

1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France

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Julien Renaud

1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France

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Ian W. Sutherland

2United States Navy Entomology. Center of Excellence, NAS Jacksonville, Florida, United States of America

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Jeffrey C. Hertz

3US Naval Medical Research Unit No. 2, Singapore

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Jean-Marc Bonneville

1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France

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Victor Arnaud

1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France

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Camille Noûs

4Laboratoire Cogitamus, 1 ¾ rue Descartes, 75005 Paris, France

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Bénédicte Fustec

5Department of Microbiology, Khon Kaen University, Khon Kaen, Thailand

6Institut de Recherche pour le Développement, UMR IRD 224-CNRS 5290-Université Montpellier. 911, avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, FRANCE

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Sébastien Boyer

7Medical and Veterinary Entomology, Institut Pasteur du Cambodge, P.O Box. 983 Phnom Penh, Cambodia

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Sébastien Marcombe

8Medical Entomology and Vector-Borne Disease Laboratory, Institut Pasteur du Laos, Vientiane, Laos

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Jean-Philippe David

1Laboratoire d’Ecologie Alpine (LECA), UMR 5553 CNRS – Université Grenoble-Alpes, 2233 rue de la piscine, Grenoble, France

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A genomic amplification affecting a carboxylesterase gene cluster confers organophosphate resistance in the mosquito Aedes aegypti: from genomic characterization to high-throughput field detection

bioRxiv 2020.06.08.139741; doi: https://doi.org/10.1101/2020.06.08.139741

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A genomic amplification affecting a carboxylesterase gene cluster confers organophosphate resistance in the mosquito Aedes aegypti: from genomic characterization to high-throughput field detection

bioRxiv 2020.06.08.139741; doi: https://doi.org/10.1101/2020.06.08.139741

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