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Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity Nanobody

Guillermo Valenzuela Nieto, Ronald Jara, Daniel Watterson, Naphak Modhiran, Alberto A Amarilla, Johanna Himelreichs, Alexander A. Khromykh, Constanza Salinas, Teresa Pinto, Yorka Cheuquemilla, Yago Margolles, Natalia López González del Rey, Zaray Miranda-Chacon, Alexei Cuevas, Anne Berking, Camila Deride, Sebastián González-Moraga, Héctor Mancilla, Daniel Maturana, Andreas Langer, Juan Pablo Toledo, Ananda Müller, Benjamín Uberti, Paola Krall, Pamela Ehrenfeld, Javier Blesa, Pedro Chana-Cuevas, German Rehren, David Schwefel, Luis Ángel Fernandez, Alejandro Rojas-Fernandez
doi: https://doi.org/10.1101/2020.06.09.137935
Guillermo Valenzuela Nieto
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
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Ronald Jara
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
2Institute of Biochemistry and Microbiology, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile
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Daniel Watterson
3School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, Australia
4The Australian Institute for Biotechnology and Nanotechnology, The University of Queensland, Brisbane, Australia
5Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Australia
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Naphak Modhiran
3School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, Australia
4The Australian Institute for Biotechnology and Nanotechnology, The University of Queensland, Brisbane, Australia
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Alberto A Amarilla
3School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, Australia
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Johanna Himelreichs
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
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Alexander A. Khromykh
3School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, Australia
5Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Australia
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Constanza Salinas
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
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Teresa Pinto
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
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Yorka Cheuquemilla
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
7Comprehensive Neuroscience Center AC (CINAC), HM Puerta del Sur, Madrid Mostoles Hospital, 28938 Madrid, Spain
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Yago Margolles
6Department of Microbial Biotechnology, National Biotechnology Center, Superior Council of Scientific Research, Madrid, Spain
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Natalia López González del Rey
7Comprehensive Neuroscience Center AC (CINAC), HM Puerta del Sur, Madrid Mostoles Hospital, 28938 Madrid, Spain
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Zaray Miranda-Chacon
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
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Alexei Cuevas
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
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Anne Berking
8Berking Biotechnology, Valdivia, Chile
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Camila Deride
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
11Institute of Veterinary Clinical Sciences, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile
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Sebastián González-Moraga
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
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Héctor Mancilla
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
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Daniel Maturana
9NanoTemper Technologies GmbH, Floessergasse 4, 81369 Munich, Germany
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Andreas Langer
9NanoTemper Technologies GmbH, Floessergasse 4, 81369 Munich, Germany
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Juan Pablo Toledo
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
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Ananda Müller
10Ross University School of Veterinary Medicine, Saint Kitts and Nevis, West Indies
11Institute of Veterinary Clinical Sciences, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile
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Benjamín Uberti
11Institute of Veterinary Clinical Sciences, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile
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Paola Krall
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
12Department of Pediatrics and Children’s Surgery Oriente, Universidad de Chile
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Pamela Ehrenfeld
13Institute of Anatomy, Histology, and Pathology, Faculty of Medicine, Universidad Austral de Chile
17Center for Interdisciplinary Studies on the Nervous System, CISNE, Universidad Austral de Chile, Valdivia, Chile
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Javier Blesa
7Comprehensive Neuroscience Center AC (CINAC), HM Puerta del Sur, Madrid Mostoles Hospital, 28938 Madrid, Spain
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Pedro Chana-Cuevas
14CETRAM & Faculty of Medical Science Universidad de Santiago de Chile, Chile
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German Rehren
15Technology Transfer and Licensing office, Universidad Austral de Chile, Valdivia, Chile
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David Schwefel
16Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Luis Ángel Fernandez
6Department of Microbial Biotechnology, National Biotechnology Center, Superior Council of Scientific Research, Madrid, Spain
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Alejandro Rojas-Fernandez
1Institute of Medicine, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
8Berking Biotechnology, Valdivia, Chile
17Center for Interdisciplinary Studies on the Nervous System, CISNE, Universidad Austral de Chile, Valdivia, Chile
18Institute of Philosophy and Complexity Sciences, Santiago, Chile
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  • For correspondence: alejandro.rojas@uach.cl
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Posted September 03, 2020.
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Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity Nanobody
Guillermo Valenzuela Nieto, Ronald Jara, Daniel Watterson, Naphak Modhiran, Alberto A Amarilla, Johanna Himelreichs, Alexander A. Khromykh, Constanza Salinas, Teresa Pinto, Yorka Cheuquemilla, Yago Margolles, Natalia López González del Rey, Zaray Miranda-Chacon, Alexei Cuevas, Anne Berking, Camila Deride, Sebastián González-Moraga, Héctor Mancilla, Daniel Maturana, Andreas Langer, Juan Pablo Toledo, Ananda Müller, Benjamín Uberti, Paola Krall, Pamela Ehrenfeld, Javier Blesa, Pedro Chana-Cuevas, German Rehren, David Schwefel, Luis Ángel Fernandez, Alejandro Rojas-Fernandez
bioRxiv 2020.06.09.137935; doi: https://doi.org/10.1101/2020.06.09.137935
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Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity Nanobody
Guillermo Valenzuela Nieto, Ronald Jara, Daniel Watterson, Naphak Modhiran, Alberto A Amarilla, Johanna Himelreichs, Alexander A. Khromykh, Constanza Salinas, Teresa Pinto, Yorka Cheuquemilla, Yago Margolles, Natalia López González del Rey, Zaray Miranda-Chacon, Alexei Cuevas, Anne Berking, Camila Deride, Sebastián González-Moraga, Héctor Mancilla, Daniel Maturana, Andreas Langer, Juan Pablo Toledo, Ananda Müller, Benjamín Uberti, Paola Krall, Pamela Ehrenfeld, Javier Blesa, Pedro Chana-Cuevas, German Rehren, David Schwefel, Luis Ángel Fernandez, Alejandro Rojas-Fernandez
bioRxiv 2020.06.09.137935; doi: https://doi.org/10.1101/2020.06.09.137935

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