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Diffuse neural coupling mediates complex network dynamics through the formation of quasi-critical brain states

View ORCID ProfileEli J. Müller, Brandon Munn, View ORCID ProfileJames M. Shine
doi: https://doi.org/10.1101/2020.06.09.141416
Eli J. Müller
1Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia
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  • For correspondence: eli.muller@sydney.edu.au
Brandon Munn
1Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia
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James M. Shine
1Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia
2Complex Systems Research Group, The University of Sydney, Sydney, NSW, Australia
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Abstract

The biological mechanisms that allow the brain to balance flexibility and integration remain poorly understood. A potential solution to this mystery may lie in a unique aspect of neurobiology, which is that numerous brain systems contain diffuse synaptic connectivity. In this manuscript, we demonstrate that increasing diffuse cortical coupling within a validated biophysical corticothalamic model traverses the system through a quasi-critical regime in which spatial heterogeneities in input noise support transient critical dynamics in distributed sub-regions. We then demonstrate that the presence of quasi-critical states coincides with known signatures of complex, adaptive brain network dynamics. Finally, we demonstrate the presence of similar dynamic signatures in empirical whole brain human neuroimaging data. Together, our results establish that modulating the balance between local and diffuse synaptic coupling in a thalamocortical model subtends the emergence of quasi-critical brain states that act to flexibly transition the brain between unique modes of information processing.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 10, 2020.
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Diffuse neural coupling mediates complex network dynamics through the formation of quasi-critical brain states
Eli J. Müller, Brandon Munn, James M. Shine
bioRxiv 2020.06.09.141416; doi: https://doi.org/10.1101/2020.06.09.141416
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Diffuse neural coupling mediates complex network dynamics through the formation of quasi-critical brain states
Eli J. Müller, Brandon Munn, James M. Shine
bioRxiv 2020.06.09.141416; doi: https://doi.org/10.1101/2020.06.09.141416

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