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History
- June 11, 2020.
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Jelena Scekic-Zahirovic1,*,
- Inmaculada Sanjuan-Ruiz1,*,
- Vanessa Kan2,3,
- Salim Megat1,
- Pierre De Rossi4,
- Stéphane Dieterlé1,
- Raphaelle Cassel1,5,
- Pascal Kessler6,
- Diana Wiesner7,8,
- Laura Tzeplaeff5,
- Valérie Demais9,
- Hans-Peter Muller7,
- Gina Picchiarelli1,
- Nibha Mishra10,11,
- Sylvie Dirrig-Grosch1,
- Jan Kassubek7,
- Volker Rasche7,
- Albert Ludolph7,8,
- Anne-Laurence Boutillier5,
- Magdalini Polymenidou4,
- Clotilde Lagier-Tourenne10,11,
- Sabine Liebscher2,3,12,# and
- Luc Dupuis1,#
- 1Université de Strasbourg, Inserm, Mécanismes centraux et périphériques de la neurodégénérescence, UMR-S1118, Strasbourg, France
- 2Institute of Clinical Neuroimmunology, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Munich. Germany
- 3BioMedical Center, Medical Faculty, Ludwig-Maximilians-University Munich, Munich, Germany
- 4Department of Quantitative Biomedicine, University of Zurich
- 5Université de Strasbourg, UMR 7364 CNRS, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France
- 6Université de Strasbourg, Inserm, Unité mixte de service du CRBS, UMS 038, Strasbourg, France
- 7Department of Neurology, University of Ulm
- 8Deutsches Zentrum für Neurodegenerative Erkrankungen, Ulm
- 9Plateforme Imagerie In Vitro, CNRS UPS-3156, NeuroPôle, Strasbourg, France
- 10Department of Neurology, The Sean M. Healey and AMG Center for ALS at Mass General, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
- 11Broad Institute of Harvard University and MIT, Cambridge, MA, USA
- 12Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
- ↵#Correspondance: Luc DUPUIS, Université de Strasbourg, Inserm, Mécanismes centraux et périphériques de la neurodégénérescence, UMR-S1118, Faculté de médecine, 11 rue Humann, 67085 Strasbourg, Cédex, France, e-mail : ldupuis{at}unistra.fr, Sabine LIEBSCHER: Institute of Clinical Neuroimmunology, Klinikum der Universität München, BioMedical Center, Grosshaderner Str. 9, 82152 Martinsried, e-mail: sabine.liebscher{at}med.uni-muenchen.de
Posted June 11, 2020.
Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses
