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Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses
Jelena Scekic-Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa Kan, Salim Megat, Pierre De Rossi, Stéphane Dieterlé, Raphaelle Cassel, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valérie Demais, Hans-Peter Muller, Gina Picchiarelli, Nibha Mishra, Sylvie Dirrig-Grosch, Jan Kassubek, Volker Rasche, Albert Ludolph, Anne-Laurence Boutillier, Magdalini Polymenidou, Clotilde Lagier-Tourenne, Sabine Liebscher, Luc Dupuis
doi: https://doi.org/10.1101/2020.06.09.141556
Jelena Scekic-Zahirovic
1Université de Strasbourg, Inserm, Mécanismes centraux et périphériques de la neurodégénérescence, UMR-S1118, Strasbourg, France
Inmaculada Sanjuan-Ruiz
1Université de Strasbourg, Inserm, Mécanismes centraux et périphériques de la neurodégénérescence, UMR-S1118, Strasbourg, France
Vanessa Kan
2Institute of Clinical Neuroimmunology, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Munich. Germany
3BioMedical Center, Medical Faculty, Ludwig-Maximilians-University Munich, Munich, Germany
Salim Megat
1Université de Strasbourg, Inserm, Mécanismes centraux et périphériques de la neurodégénérescence, UMR-S1118, Strasbourg, France
Pierre De Rossi
4Department of Quantitative Biomedicine, University of Zurich
Stéphane Dieterlé
1Université de Strasbourg, Inserm, Mécanismes centraux et périphériques de la neurodégénérescence, UMR-S1118, Strasbourg, France
Raphaelle Cassel
1Université de Strasbourg, Inserm, Mécanismes centraux et périphériques de la neurodégénérescence, UMR-S1118, Strasbourg, France
5Université de Strasbourg, UMR 7364 CNRS, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France
Pascal Kessler
6Université de Strasbourg, Inserm, Unité mixte de service du CRBS, UMS 038, Strasbourg, France
Diana Wiesner
7Department of Neurology, University of Ulm
8Deutsches Zentrum für Neurodegenerative Erkrankungen, Ulm
Laura Tzeplaeff
5Université de Strasbourg, UMR 7364 CNRS, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France
Valérie Demais
9Plateforme Imagerie In Vitro, CNRS UPS-3156, NeuroPôle, Strasbourg, France
Hans-Peter Muller
7Department of Neurology, University of Ulm
Gina Picchiarelli
1Université de Strasbourg, Inserm, Mécanismes centraux et périphériques de la neurodégénérescence, UMR-S1118, Strasbourg, France
Nibha Mishra
10Department of Neurology, The Sean M. Healey and AMG Center for ALS at Mass General, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
11Broad Institute of Harvard University and MIT, Cambridge, MA, USA
Sylvie Dirrig-Grosch
1Université de Strasbourg, Inserm, Mécanismes centraux et périphériques de la neurodégénérescence, UMR-S1118, Strasbourg, France
Jan Kassubek
7Department of Neurology, University of Ulm
Volker Rasche
7Department of Neurology, University of Ulm
Albert Ludolph
7Department of Neurology, University of Ulm
8Deutsches Zentrum für Neurodegenerative Erkrankungen, Ulm
Anne-Laurence Boutillier
5Université de Strasbourg, UMR 7364 CNRS, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France
Magdalini Polymenidou
4Department of Quantitative Biomedicine, University of Zurich
Clotilde Lagier-Tourenne
10Department of Neurology, The Sean M. Healey and AMG Center for ALS at Mass General, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
11Broad Institute of Harvard University and MIT, Cambridge, MA, USA
Sabine Liebscher
2Institute of Clinical Neuroimmunology, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Munich. Germany
3BioMedical Center, Medical Faculty, Ludwig-Maximilians-University Munich, Munich, Germany
12Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
Luc Dupuis
1Université de Strasbourg, Inserm, Mécanismes centraux et périphériques de la neurodégénérescence, UMR-S1118, Strasbourg, France
Posted June 11, 2020.
Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses
Jelena Scekic-Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa Kan, Salim Megat, Pierre De Rossi, Stéphane Dieterlé, Raphaelle Cassel, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valérie Demais, Hans-Peter Muller, Gina Picchiarelli, Nibha Mishra, Sylvie Dirrig-Grosch, Jan Kassubek, Volker Rasche, Albert Ludolph, Anne-Laurence Boutillier, Magdalini Polymenidou, Clotilde Lagier-Tourenne, Sabine Liebscher, Luc Dupuis
bioRxiv 2020.06.09.141556; doi: https://doi.org/10.1101/2020.06.09.141556
Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses
Jelena Scekic-Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa Kan, Salim Megat, Pierre De Rossi, Stéphane Dieterlé, Raphaelle Cassel, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valérie Demais, Hans-Peter Muller, Gina Picchiarelli, Nibha Mishra, Sylvie Dirrig-Grosch, Jan Kassubek, Volker Rasche, Albert Ludolph, Anne-Laurence Boutillier, Magdalini Polymenidou, Clotilde Lagier-Tourenne, Sabine Liebscher, Luc Dupuis
bioRxiv 2020.06.09.141556; doi: https://doi.org/10.1101/2020.06.09.141556
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