Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice

Sonu Sahadevan; Katharina M. Hembach; Elena Tantardini; Manuela Pérez-Berlanga; Marian Hruska-Plochan; Julien Weber; Petra Schwarz; Luc Dupuis; Mark D. Robinson; Pierre De Rossi; Magdalini Polymenidou

doi:10.1101/2020.06.10.136010

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Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice

Sonu Sahadevan, Katharina M. Hembach, Elena Tantardini, Manuela Pérez-Berlanga, Marian Hruska-Plochan, Julien Weber, Petra Schwarz, Luc Dupuis, Mark D. Robinson, Pierre De Rossi, Magdalini Polymenidou

doi: https://doi.org/10.1101/2020.06.10.136010

Sonu Sahadevan

1Department of Quantitative Biomedicine, University of Zurich

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Katharina M. Hembach

1Department of Quantitative Biomedicine, University of Zurich

2Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich

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Elena Tantardini

1Department of Quantitative Biomedicine, University of Zurich

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Manuela Pérez-Berlanga

1Department of Quantitative Biomedicine, University of Zurich

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Marian Hruska-Plochan

1Department of Quantitative Biomedicine, University of Zurich

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Julien Weber

1Department of Quantitative Biomedicine, University of Zurich

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Petra Schwarz

3Institute of Neuropathology, University Hospital Zurich

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Luc Dupuis

4Inserm, University of Strasbourg

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Mark D. Robinson

2Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich

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Pierre De Rossi

1Department of Quantitative Biomedicine, University of Zurich

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Magdalini Polymenidou

1Department of Quantitative Biomedicine, University of Zurich

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For correspondence: magdalini.polymenidou@uzh.ch

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Posted June 10, 2020.

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Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice

bioRxiv 2020.06.10.136010; doi: https://doi.org/10.1101/2020.06.10.136010

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Synaptic accumulation of FUS triggers age-dependent misregulation of inhibitory synapses in ALS-FUS mice

bioRxiv 2020.06.10.136010; doi: https://doi.org/10.1101/2020.06.10.136010

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