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The influence of Schizotypy on Event-Related Oscillations in Sensory Gating during early Infant Development

View ORCID ProfileEleanor S. Smith, Trevor J. Crawford, Vincent M. Reid
doi: https://doi.org/10.1101/2020.06.10.144014
Eleanor S. Smith
1Department of Psychology, Lancaster University, Bailrigg, Lancaster, United Kingdom, LA1 4YF
2Department of Experimental Psychology, Downing Site, Downing Street, Cambridge, United Kingdom, CB2 3EB
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  • ORCID record for Eleanor S. Smith
  • For correspondence: ess46@cam.ac.uk
Trevor J. Crawford
1Department of Psychology, Lancaster University, Bailrigg, Lancaster, United Kingdom, LA1 4YF
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Vincent M. Reid
1Department of Psychology, Lancaster University, Bailrigg, Lancaster, United Kingdom, LA1 4YF
3School of Psychology, University of Waikato, Hamilton, New Zealand
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Abstract

Maternal schizotypic personality is thought to influence childhood risk for mental health and is a personality dimension elevated among schizophrenia-spectrum patients and their first-degree relatives, in whom neuro-oscillatory deficits have been observed. The current study investigated whether 6-month-old infants (n =46), and a subset of their biological mothers (n =34), who identified as either schizotypic (n =14) non-schizotypic (n =14), or an intermediate group (n =6), displayed reduced evoked-oscillatory activity. All mothers completed the Oxford-Liverpool Inventory of Feelings and Experiences as an index of schizotypy dimensionality. An auditory paired-tone paradigm was used to probe oscillatory activity, revealing that although the infants’ evoked-oscillations displayed differences between Stimulus 1 and 2, there were no group differences between infants of schizotypic and control mothers. Their mothers, however, displayed differences, with reduced amplitudes toward Stimulus 1 in schizotypic mothers; consistent with literature on early sensory processes, showing sensory gating is impaired in schizophrenia-spectrum disorders.

Footnotes

  • There are no conflicts of interest to declare.

  • Funding: The present research was funded by the Leverhulme Trust Doctoral Scholarship Programme in Interdisciplinary Research on Infant Development.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 10, 2020.
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The influence of Schizotypy on Event-Related Oscillations in Sensory Gating during early Infant Development
Eleanor S. Smith, Trevor J. Crawford, Vincent M. Reid
bioRxiv 2020.06.10.144014; doi: https://doi.org/10.1101/2020.06.10.144014
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The influence of Schizotypy on Event-Related Oscillations in Sensory Gating during early Infant Development
Eleanor S. Smith, Trevor J. Crawford, Vincent M. Reid
bioRxiv 2020.06.10.144014; doi: https://doi.org/10.1101/2020.06.10.144014

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