Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Medial entorhinal spike clusters carry more finely tuned spatial information than single spikes

View ORCID ProfileLeo. Richard Quinlan, View ORCID ProfileSusan. Margot Tyree, View ORCID ProfileRobert. Gordon. Keith. Munn
doi: https://doi.org/10.1101/2020.06.10.144204
Leo. Richard Quinlan
2Discipline of Physiology, National University of Ireland, Galway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Leo. Richard Quinlan
Susan. Margot Tyree
3Department of Neurobiology, Stanford University School of Medicine
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Susan. Margot Tyree
Robert. Gordon. Keith. Munn
1Discipline of Pharmacology, National University of Ireland, Galway
3Department of Neurobiology, Stanford University School of Medicine
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Robert. Gordon. Keith. Munn
  • For correspondence: robert.munn@nuigalway.ie
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Many cells within the entorhinal cortex (EC) fire relatively infrequently, with the majority of their spikes separated by many hundreds of milliseconds. However, most cells are seen to occasionally fire two, three, or more spikes in quick succession. Recent evidence has shown that, in EC grid cells, “burstier” cells; cells that fire more of their spikes in bursts, have more well defined spatial characteristics than cells that fire fewer bursts. However, there is evidence that the window for considering related spikes in MEC could be as long as 100ms. Here, we divide the spikes fired by single cells into single spikes and “clusters” of spikes occuring within 100ms. We show that these burst “clusters” of spikes fired by cells in MEC convey more finely tuned spatial and directional information than the numerically more common single spikes. In addition, we find that introducing environmental uncertainty decreases the ratio of clusters fired to single spikes. Most crucially, we find that although single spikes are less spatially precise than clusters, they are more temporally precise – these spikes are more closely entrained to LFP theta than clusters. These findings demonstrate that clusters of spikes in EC convey more specific information about space than single spikes, may reflect “certainty” about spatial position and direction, and may represent a different firing “mode” in which intraregional communication is less relevant than interregional traffic.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted June 12, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Medial entorhinal spike clusters carry more finely tuned spatial information than single spikes
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Medial entorhinal spike clusters carry more finely tuned spatial information than single spikes
Leo. Richard Quinlan, Susan. Margot Tyree, Robert. Gordon. Keith. Munn
bioRxiv 2020.06.10.144204; doi: https://doi.org/10.1101/2020.06.10.144204
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Medial entorhinal spike clusters carry more finely tuned spatial information than single spikes
Leo. Richard Quinlan, Susan. Margot Tyree, Robert. Gordon. Keith. Munn
bioRxiv 2020.06.10.144204; doi: https://doi.org/10.1101/2020.06.10.144204

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (2540)
  • Biochemistry (4990)
  • Bioengineering (3492)
  • Bioinformatics (15264)
  • Biophysics (6922)
  • Cancer Biology (5415)
  • Cell Biology (7762)
  • Clinical Trials (138)
  • Developmental Biology (4551)
  • Ecology (7175)
  • Epidemiology (2059)
  • Evolutionary Biology (10252)
  • Genetics (7527)
  • Genomics (9818)
  • Immunology (4884)
  • Microbiology (13278)
  • Molecular Biology (5159)
  • Neuroscience (29538)
  • Paleontology (203)
  • Pathology (840)
  • Pharmacology and Toxicology (1469)
  • Physiology (2149)
  • Plant Biology (4772)
  • Scientific Communication and Education (1015)
  • Synthetic Biology (1340)
  • Systems Biology (4017)
  • Zoology (770)