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An integrative study of five biological clocks in somatic and mental health

View ORCID ProfileRick Jansen, Josine Verhoeven, Laura KM Han, Karolina A Aberg, Edwin CGJ van den Oord, Yuri Milaneschi, Brenda WJH Penninx
doi: https://doi.org/10.1101/2020.06.11.146498
Rick Jansen
aDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Oldenaller 1, Amsterdam, The Netherlands
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  • For correspondence: ri.jansen@ggzingeest.nl
Josine Verhoeven
aDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Oldenaller 1, Amsterdam, The Netherlands
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Laura KM Han
aDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Oldenaller 1, Amsterdam, The Netherlands
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Karolina A Aberg
bCenter for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USA
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Edwin CGJ van den Oord
bCenter for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USA
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Yuri Milaneschi
aDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Oldenaller 1, Amsterdam, The Netherlands
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Brenda WJH Penninx
aDepartment of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Oldenaller 1, Amsterdam, The Netherlands
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ABSTRACT

Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illnesses and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether 5 biological clocks (telomere length, epigenetic, transcriptomic, proteomic and metabolomic clocks) were interrelated and associated to somatic and mental health determinants. Correlations between biological clocks were small (all r<0.2), indicating little overlap. The most consistent associations with the advanced biological clocks were found for male sex, higher BMI, metabolic syndrome, smoking and depression. As compared to the individual clocks, a composite index of all five clocks showed most pronounced associations with health determinants. The large effect sizes of the composite index and the low correlation between biological clocks, indicate that one’s biological age is best reflected by combining aging measures from multiple cellular levels.

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  • ↵* shared first author

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 12, 2020.
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An integrative study of five biological clocks in somatic and mental health
Rick Jansen, Josine Verhoeven, Laura KM Han, Karolina A Aberg, Edwin CGJ van den Oord, Yuri Milaneschi, Brenda WJH Penninx
bioRxiv 2020.06.11.146498; doi: https://doi.org/10.1101/2020.06.11.146498
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An integrative study of five biological clocks in somatic and mental health
Rick Jansen, Josine Verhoeven, Laura KM Han, Karolina A Aberg, Edwin CGJ van den Oord, Yuri Milaneschi, Brenda WJH Penninx
bioRxiv 2020.06.11.146498; doi: https://doi.org/10.1101/2020.06.11.146498

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