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Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

Lydia J Finney, Nicholas Glanville, Hugo Farne, Julia Aniscenko, Peter Fenwick, Samuel V Kemp, Maria-Belen Trujillo-Torralbo, Maria Adelaide Calderazzo, Jadwiga A Wedzicha, Patrick Mallia, Nathan W Bartlett, Sebastian L Johnston, Aran Singanayagam
doi: https://doi.org/10.1101/2020.06.13.149039
Lydia J Finney
1National Heart and Lung Institute, Imperial College London
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Nicholas Glanville
2Prokarium, London BioScience Innovation Centre, 2 Royal College Street, London NW1 0NH
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Hugo Farne
1National Heart and Lung Institute, Imperial College London
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Julia Aniscenko
1National Heart and Lung Institute, Imperial College London
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Peter Fenwick
1National Heart and Lung Institute, Imperial College London
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Samuel V Kemp
1National Heart and Lung Institute, Imperial College London
3Royal Brompton and Harefield NHS Trust
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Maria-Belen Trujillo-Torralbo
1National Heart and Lung Institute, Imperial College London
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Maria Adelaide Calderazzo
1National Heart and Lung Institute, Imperial College London
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Jadwiga A Wedzicha
1National Heart and Lung Institute, Imperial College London
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Patrick Mallia
1National Heart and Lung Institute, Imperial College London
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Nathan W Bartlett
4Faculty of Health and Medicine and Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle
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Sebastian L Johnston
1National Heart and Lung Institute, Imperial College London
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Aran Singanayagam
1National Heart and Lung Institute, Imperial College London
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  • For correspondence: a.singanayagam@imperial.ac.uk
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Posted June 15, 2020.
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Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
Lydia J Finney, Nicholas Glanville, Hugo Farne, Julia Aniscenko, Peter Fenwick, Samuel V Kemp, Maria-Belen Trujillo-Torralbo, Maria Adelaide Calderazzo, Jadwiga A Wedzicha, Patrick Mallia, Nathan W Bartlett, Sebastian L Johnston, Aran Singanayagam
bioRxiv 2020.06.13.149039; doi: https://doi.org/10.1101/2020.06.13.149039
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Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
Lydia J Finney, Nicholas Glanville, Hugo Farne, Julia Aniscenko, Peter Fenwick, Samuel V Kemp, Maria-Belen Trujillo-Torralbo, Maria Adelaide Calderazzo, Jadwiga A Wedzicha, Patrick Mallia, Nathan W Bartlett, Sebastian L Johnston, Aran Singanayagam
bioRxiv 2020.06.13.149039; doi: https://doi.org/10.1101/2020.06.13.149039

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