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Mathematical connection between short telomere induced senescence calculation and mortality rate data

View ORCID ProfileJerry B. Torrance, Steve Goldband
doi: https://doi.org/10.1101/2020.06.15.152348
Jerry B. Torrance
1Physical Science Department, IBM Almaden Research Center, San Jose, CA USA (emeritus, retired)
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  • For correspondence: jerry@torrtiz.com
Steve Goldband
2Stanford Center on Longevity, Stanford University, Stanford CA USA (retired)
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Abstract

The last 20 years have seen a surge in scientific activity and promising results in the study of aging and longevity. Many researchers have focused on telomeres, which are composed of a series of TTAGGG repeat nucleotide sequences at the ends of each chromosome. Measurements of the length of these telomere strands show that they decrease in length with increasing age, leading many authors to propose that when the length of these telomere strands decreases sufficiently, the cells enter into a state of replicative senescence, eventually leading to disease and death. These ideas are supported by evidence that short telomere length is correlated with increased mortality. In this paper, we extend this idea to make an actual calculation of the predicted mortality rate caused by short telomere length induced senescence (STLIS). We derive a simple equation for the mathematical relationship between telomere length and mortality rate. Using only 3 parameters based on telomere length measurement data of Canadians, we have calculated both the magnitude and the age dependence of the mortality rate, for both men and women. We show that these calculated data are in good quantitative agreement with the actual number of Canadians that die. This agreement provides strong evidence (but not proof) that the mechanism of STLIS plays an important role in the major diseases of aging (e.g., cardiovascular disease, many cancers, and diabetes mellitus) which dominate human mortality. This result represents significant progress in our understanding the factors behind the cause of aging.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 15, 2020.
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Mathematical connection between short telomere induced senescence calculation and mortality rate data
Jerry B. Torrance, Steve Goldband
bioRxiv 2020.06.15.152348; doi: https://doi.org/10.1101/2020.06.15.152348
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Mathematical connection between short telomere induced senescence calculation and mortality rate data
Jerry B. Torrance, Steve Goldband
bioRxiv 2020.06.15.152348; doi: https://doi.org/10.1101/2020.06.15.152348

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