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- June 29, 2020.
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- Siddhartha P. Kar1,2,†,
- Sara Lindström3,4,
- Rayjean J. Hung5,
- Kate Lawrenson6,7,
- Marjanka K. Schmidt8,9,
- Tracy A. O’Mara10,
- Dylan M. Glubb10,
- Jonathan P. Tyrer11,
- Joellen M. Schildkraut12,
- Jenny Chang-Claude13,14,
- Ahmad G. M. Alsulimani15,
- Fernando M. Antón16,
- Alicia Beeghly-Fadiel17,
- Line Bjørge18,19,
- Clara Bodelon20,
- Hiltrud Brauch21,22,23,
- Stefanie Burghaus24,
- Daniele Campa25,26,
- Michael Carney27,
- Chu Chen28,29,
- Zhihua Chen30,
- Mary B. Daly31,
- Andreas du Bois32,
- Arif B. Ekici33,34,
- Ailith Ewing35,
- Peter Fasching36,37,
- James M. Flanagan38,
- Jan Gawelko39,
- Graham G. Giles40,41,42,
- Robert J. Hamilton43,
- Holly R. Harris28,
- Florian Heitz44,45,46,
- Michelle Hildebrandt47,
- Peter Hillemanns48,
- Ruea-Yea Huang49,
- Liher Imaz50,51,
- Arvids Irmejs52,
- Anna Jakubowska53,54,
- Allan Jensen55,
- Esther M. John56,57,
- Päivi Kannisto58,
- Beth Y. Karlan59,
- Elza Khusnutdinova60,
- Lambertus A. Kiemeney61,
- Susanne K. Kjaer55,62,
- Rüdiger Klapdor48,
- Petra Kleiblova63,
- Martin Köbel64,
- Bozena Konopka65,
- Camilla Krakstad66,67,
- Davor Lessel68,
- Artitaya Lophatananon69,
- Taymaa May70,
- Agnieszka D. Mieszkowska65,
- Alvaro N. Monteiro30,
- Kirsten Moysich15,
- Kenneth Muir69,
- Sune F. Nielsen71,
- Kunle Odunsi49,72,
- Håkan Olsson73,
- Tjoung-Won Park-Simon74,
- Jennifer B. Permuth75,
- Paolo Peterlongo76,
- Agnieszka Podgorski65,
- Ross Prentice77,
- Paolo Radice78,
- Harvey A. Risch79,
- Ingo B. Runnebaum80,
- Iwona K. Rzepecka65,
- Rodney J. Scott81,82,83,
- Veronica W. Setiawan84,
- Nadeem Siddiqui85,
- Weiva Sieh86,
- Beata Śpiewankiewicz87,
- Lukasz M. Szafron88,
- Cheryl L. Thompson89,
- Linda J. Titus90,
- Clare Turnbull91,92,93,
- Nawaid Usmani94,
- Anne M. van Altena95,
- Ana Vega-Gliemmo96,
- Ignace Vergote97,
- Robert A. Vierkant98,
- Joseph Vijai99,100,101,
- Stacey J. Winham98,
- Robert Winqvist102,103,
- Herbert Yu104,
- the PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS105,
- Diether Lambrechts106,107,
- Deborah J. Thompson11,
- Ellen L. Goode108,
- Wei Zheng17,
- Ian P. M. Tomlinson109,
- Andrew Berchuck110,
- Susan J. Ramus111,
- Stephen J. Chanock112,
- Douglas F. Easton11,113,
- Georgia Chenevix-Trench10,
- Simon A. Gayther6,
- Amanda B. Spurdle10,
- Rosalind A. Eeles114,115,
- Peter Kraft116,117 and
- Paul D. P. Pharoah11,113
- 1Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK
- 2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
- 3Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA
- 4Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
- 5Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Canada
- 6Center for Bioinformatics and Functional Genomics, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA
- 7Women’s Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
- 8Division of Molecular Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands
- 9Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands
- 10Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia
- 11Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
- 12Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
- 13Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
- 14Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- 15Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
- 16Hospital Clínico San Carlos, Madrid, Spain
- 17Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
- 18Department of Obstetrics and Gynecology, Haukeland University, Hospital, Bergen, Norway
- 19Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway
- 20Divison of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
- 21Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
- 22iFIT Cluster of Excellence, University of Tübingen, Tübingen, Germany
- 23German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Partner Site Tübingen, Tübingen, Germany
- 24Frauenklinik, Universitätsklinikum Erlangen, Erlangen, Germany
- 25Division of Cancer Epidemiology, DKFZ, Heidelberg, Germany
- 26Department of Biology, University of Pisa, Pisa, Italy
- 27Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
- 28Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
- 29Department of Epidemiology, University of Washington, Seattle, WA, USA
- 30Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
- 31Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA
- 32Department of Gynecology and Gynecologic Oncology, Evang. Kliniken Essen-Mitte, Essen, Germany
- 33Institute of Human Genetics, University Hospital Erlangen, Erlangen, Germany
- 34Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen, Erlangen, Germany
- 35MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Edinburgh, UK
- 36David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles. Los Angeles, CA, USA
- 37Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
- 38Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
- 39Medical College Rzeszow University
- 40Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia
- 41Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
- 42Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
- 43Division of Urology, Department of Surgery, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada
- 44Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/ Evang., Essen, Germany
- 45Department of Gynecology, Center for Oncologic Surgery, Charité Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany
- 46Freie Universität Berlin, Humboldt-Universität of Berlin, and Berlin Institute of Health, Berlin, Germany
- 47Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
- 48Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany
- 49Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA
- 50Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, Donostia-San Sebastian, Spain
- 51Biodonostia Health Research Institute, Donostia-San Sebastian, Spain
- 52Riga Stradins University, Pauls Stradins Clinical University Hospital, Riga, Latvia
- 53Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland
- 54Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland
- 55Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark
- 56Cancer Prevention Institute of California, Fremont, CA, USA
- 57Division of Oncology and Stanford Cancer Institute, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
- 58Department of Obstetrics and Gynecology, University of Lund, Lund, Sweden
- 59David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA
- 60Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia
- 61Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
- 62Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
- 63Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
- 64Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, Canada
- 65Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
- 66Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
- 67Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway
- 68Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- 69Division of Population Health, Health Services Research and Primary Care, Faculty of Biology, Medicine and Health, Centre for Epidemiology, University of Manchester, Manchester, UK
- 70Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Canada
- 71Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
- 72Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
- 73Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden
- 74Department of Gynecology, Hannover Medical School, Hannover, Germany
- 75Departments of Cancer Epidemiology and Gastrointestinal Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL
- 76Genome Diagnostics Program, IFOM-The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy
- 77Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
- 78Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy
- 79Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT
- 80Department for Gynaecology and Reproductive Medicine, Jena University Hospital-Friedrich Schiller University Jena, Jena, Germany
- 81Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, Australia
- 82Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, Australia
- 83Hunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia
- 84Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 85Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK
- 86Department of Population Health Science and Policy, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- 87Department of Gynecologic Oncology, Institute of Oncology, Warsaw, Poland
- 88Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
- 89Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA
- 90Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
- 91Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK
- 92Department of Clinical Genetics, Royal Marsden NHS Foundation Trust, London, UK
- 93Public Health England, National Cancer Registration and Analysis Service, London, UK
- 94Department of Radiation Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Canada
- 95Radboud University Medical Centre, Department of Obstetrics and Gynecology, Nijmegen, The Netherlands
- 96Galician Public Foundation of Genomic Medicine (FPGMX), Clinical University Hospital, Santiago de Compostela, Spain
- 97Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, KU University, Leuven, Belgium
- 98Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA
- 99Niehaus Center For Inherited Cancer Genomics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
- 100Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
- 101Department of Medicine, Weill Cornell Medical College, New York, NY, USA
- 102Biocenter Oulu, Cancer and Translational Medicine Research Unit, Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, Oulu, Finland
- 103Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland
- 104Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
- 105Members from the PRACTICAL Consortium, CRUK, BPC3, CAPS and PEGASUS are provided in the Supplementmary Notes
- 106VIB Center for Cancer Biology, VIB, Leuven, Belgium
- 107Laboratory of Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium
- 108Department of Health Sciences Research, Mayo Clinic, Rochester, MN
- 109Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK
- 110Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA
- 111Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia
- 112Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
- 113Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
- 114Institute of Cancer Research, London, UK
- 115Royal Marsden NHS Foundation Trust, London, UK
- 116Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
- 117Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA
- ↵†Corresponding author:
Siddhartha Kar, MBBS, MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK, Email:
siddhartha.kar{at}bristol.ac.uk