New Results
Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs
View ORCID ProfileAnthony L. Shiver, Hendrik Osadnik, Jason M. Peters, Rachel A. Mooney, Peter I. Wu, James C. Hu, Robert Landick, Kerwyn Casey Huang, Carol A. Gross
doi: https://doi.org/10.1101/2020.06.16.155770
Anthony L. Shiver
1Graduate Group in Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
2Department of Bioengineering, Stanford University School of Medicine, Stanford, CA, 94305, USA
Hendrik Osadnik
3Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA
Jason M. Peters
3Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA
4Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin—Madison, Madison, Wisconsin, USA, Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA, Department of Medical Microbiology and Immunology, University of Wisconsin— Madison, Madison, Wisconsin, USA, Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin—Madison, Madison, Wisconsin, US
Rachel A. Mooney
5Department of Biochemistry, University of Wisconsin—Madison, Madison, WI, 53706 USA
Peter I. Wu
6Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843
James C. Hu
6Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843
Robert Landick
5Department of Biochemistry, University of Wisconsin—Madison, Madison, WI, 53706 USA
7Department of Bacteriology, University of Wisconsin—Madison, Madison, WI, 53706 USA
Kerwyn Casey Huang
2Department of Bioengineering, Stanford University School of Medicine, Stanford, CA, 94305, USA
8Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
9Chan Zuckerberg Biohub, San Francisco, CA 94158, USA
Carol A. Gross
3Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94158, USA
10Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94158, USA
11California Institute of Quantitative Biology, University of California San Francisco, San Francisco, CA, 94158, USA
Article usage
Posted June 17, 2020.
Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs
Anthony L. Shiver, Hendrik Osadnik, Jason M. Peters, Rachel A. Mooney, Peter I. Wu, James C. Hu, Robert Landick, Kerwyn Casey Huang, Carol A. Gross
bioRxiv 2020.06.16.155770; doi: https://doi.org/10.1101/2020.06.16.155770
Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs
Anthony L. Shiver, Hendrik Osadnik, Jason M. Peters, Rachel A. Mooney, Peter I. Wu, James C. Hu, Robert Landick, Kerwyn Casey Huang, Carol A. Gross
bioRxiv 2020.06.16.155770; doi: https://doi.org/10.1101/2020.06.16.155770
Subject Area
Subject Areas
- Biochemistry (11739)
- Bioengineering (8750)
- Bioinformatics (29189)
- Biophysics (14967)
- Cancer Biology (12093)
- Cell Biology (17409)
- Clinical Trials (138)
- Developmental Biology (9419)
- Ecology (14178)
- Epidemiology (2067)
- Evolutionary Biology (18301)
- Genetics (12238)
- Genomics (16797)
- Immunology (11865)
- Microbiology (28068)
- Molecular Biology (11583)
- Neuroscience (60953)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4957)
- Plant Biology (10425)
- Synthetic Biology (2884)
- Systems Biology (7338)
- Zoology (1651)