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Genome-scale genetic screening identifies PRMT1 as a critical vulnerability in castration-resistant prostate cancer
View ORCID ProfileStephen Tang, Nebiyou Y. Metaferia, Marina F. Nogueira, Maya K. Gelbard, Sarah Abou Alaiwi, Ji-Heui Seo, Justin H. Hwang, Craig A. Strathdee, Sylvan C. Baca, Jiao Li, Shatha AbuHammad, Xiaoyang Zhang, John G. Doench, William C. Hahn, David Y. Takeda, Matthew L. Freedman, View ORCID ProfilePeter S. Choi, View ORCID ProfileSrinivas R. Viswanathan
doi: https://doi.org/10.1101/2020.06.17.156034
Stephen Tang
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
2Broad Institute of MIT and Harvard, Cambridge, MA 02142
Nebiyou Y. Metaferia
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
Marina F. Nogueira
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
2Broad Institute of MIT and Harvard, Cambridge, MA 02142
Maya K. Gelbard
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
Sarah Abou Alaiwi
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
3Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215
Ji-Heui Seo
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
3Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215
Justin H. Hwang
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
2Broad Institute of MIT and Harvard, Cambridge, MA 02142
Craig A. Strathdee
2Broad Institute of MIT and Harvard, Cambridge, MA 02142
Sylvan C. Baca
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
2Broad Institute of MIT and Harvard, Cambridge, MA 02142
3Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215
Jiao Li
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
Shatha AbuHammad
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
Xiaoyang Zhang
4Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112
John G. Doench
2Broad Institute of MIT and Harvard, Cambridge, MA 02142
William C. Hahn
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
2Broad Institute of MIT and Harvard, Cambridge, MA 02142
5Harvard Medical School, Boston, MA 02215
David Y. Takeda
6Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892
Matthew L. Freedman
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
2Broad Institute of MIT and Harvard, Cambridge, MA 02142
3Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215
5Harvard Medical School, Boston, MA 02215
Peter S. Choi
7Division of Cancer Pathobiology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104
8Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104
Srinivas R. Viswanathan
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215
2Broad Institute of MIT and Harvard, Cambridge, MA 02142
5Harvard Medical School, Boston, MA 02215
Posted June 17, 2020.
Genome-scale genetic screening identifies PRMT1 as a critical vulnerability in castration-resistant prostate cancer
Stephen Tang, Nebiyou Y. Metaferia, Marina F. Nogueira, Maya K. Gelbard, Sarah Abou Alaiwi, Ji-Heui Seo, Justin H. Hwang, Craig A. Strathdee, Sylvan C. Baca, Jiao Li, Shatha AbuHammad, Xiaoyang Zhang, John G. Doench, William C. Hahn, David Y. Takeda, Matthew L. Freedman, Peter S. Choi, Srinivas R. Viswanathan
bioRxiv 2020.06.17.156034; doi: https://doi.org/10.1101/2020.06.17.156034
Genome-scale genetic screening identifies PRMT1 as a critical vulnerability in castration-resistant prostate cancer
Stephen Tang, Nebiyou Y. Metaferia, Marina F. Nogueira, Maya K. Gelbard, Sarah Abou Alaiwi, Ji-Heui Seo, Justin H. Hwang, Craig A. Strathdee, Sylvan C. Baca, Jiao Li, Shatha AbuHammad, Xiaoyang Zhang, John G. Doench, William C. Hahn, David Y. Takeda, Matthew L. Freedman, Peter S. Choi, Srinivas R. Viswanathan
bioRxiv 2020.06.17.156034; doi: https://doi.org/10.1101/2020.06.17.156034
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