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A general theory of coherence between brain areas

Marius Schneider, Benjamin Dann, Swathi Sheshadri, Hansjörg Scherberger, View ORCID ProfileMartin Vinck
doi: https://doi.org/10.1101/2020.06.17.156190
Marius Schneider
aErnst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt am Main, Germany
dInternational Max Planck Research School for Neural Circuits, Frankfurt am Main, Germany
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Benjamin Dann
bGerman Primate Center, Göttingen, Germany
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Swathi Sheshadri
bGerman Primate Center, Göttingen, Germany
cFaculty of Biology and Psychology, University of Goettingen, Germany
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Hansjörg Scherberger
bGerman Primate Center, Göttingen, Germany
cFaculty of Biology and Psychology, University of Goettingen, Germany
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Martin Vinck
aErnst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt am Main, Germany
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  • ORCID record for Martin Vinck
  • For correspondence: martin.vinck@esi-frankfurt.de
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Abstract

What does neuronal coherence tell us about neuronal communication? Does coherence between field potentials (e.g. LFP, EEG, MEG) reflect spiking entrainment or coupling between oscillators? Is it a mechanism for communication between brain areas, or a byproduct of interareal connectivity? We hypothesized that interareal coherence is explained by the fact that outputs from one cortical area give rise to synaptic inputs in the same brain area, and correlated synaptic inputs in another area. Our mathematical analysis demonstrates that coherence between a sending and receiving area is precisely predicted from only two parameters: Interareal connectivity and oscillatory synchronization in the sending area. This model predicts narrow-band coherence even in case of a flat transfer function and in the absence of spiking entrainment in a downstream area, and reproduces frequency-specific Granger-causality patterns between brain areas (gamma feedforward, beta feedback). In general, we find that Granger-causality between field potentials is dominated by oscillatory synchronization in the sending area, whereas spiking entrainment is determined by the resonant properties of the receiver. Our model accurately reproduces LFP-LFP beta-coherence between macaque areas 7B and F5 in the absence of beta phase-locking within area F5. Together, these findings uncover a precise mechanistic model of interareal coherence as a (by)product of connectivity and power.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 18, 2020.
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A general theory of coherence between brain areas
Marius Schneider, Benjamin Dann, Swathi Sheshadri, Hansjörg Scherberger, Martin Vinck
bioRxiv 2020.06.17.156190; doi: https://doi.org/10.1101/2020.06.17.156190
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A general theory of coherence between brain areas
Marius Schneider, Benjamin Dann, Swathi Sheshadri, Hansjörg Scherberger, Martin Vinck
bioRxiv 2020.06.17.156190; doi: https://doi.org/10.1101/2020.06.17.156190

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