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Nutritional status and fecundity are synchronised by muscular exopheresis

View ORCID ProfileMichał Turek, View ORCID ProfileMałgorzata Piechota, View ORCID ProfileNilesh Shanmugam, Marta Niklewicz, Konrad Kowalski, View ORCID ProfileAgnieszka Chacińska, View ORCID ProfileWojciech Pokrzywa
doi: https://doi.org/10.1101/2020.06.17.157230
Michał Turek
1Laboratory of Mitochondrial Biogenesis, Centre of New Technologies, University of Warsaw, Warsaw, Poland
2ReMedy International Research Agenda Unit, University of Warsaw, Warsaw, Poland
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  • For correspondence: wpokrzywa@iimcb.gov.pl m.turek@cent.uw.edu.pl
Małgorzata Piechota
3Laboratory of Protein Metabolism in Development and Aging, International Institute of Molecular and Cell Biology, Warsaw, Poland
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Nilesh Shanmugam
3Laboratory of Protein Metabolism in Development and Aging, International Institute of Molecular and Cell Biology, Warsaw, Poland
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Marta Niklewicz
3Laboratory of Protein Metabolism in Development and Aging, International Institute of Molecular and Cell Biology, Warsaw, Poland
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Konrad Kowalski
3Laboratory of Protein Metabolism in Development and Aging, International Institute of Molecular and Cell Biology, Warsaw, Poland
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Agnieszka Chacińska
1Laboratory of Mitochondrial Biogenesis, Centre of New Technologies, University of Warsaw, Warsaw, Poland
2ReMedy International Research Agenda Unit, University of Warsaw, Warsaw, Poland
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Wojciech Pokrzywa
3Laboratory of Protein Metabolism in Development and Aging, International Institute of Molecular and Cell Biology, Warsaw, Poland
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  • ORCID record for Wojciech Pokrzywa
  • For correspondence: wpokrzywa@iimcb.gov.pl m.turek@cent.uw.edu.pl
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Abstract

Organismal functionality and reproduction depend on metabolic rewiring and balanced energy resources. However, the crosstalk between organismal homeostasis and fecundity, and the associated paracrine signaling mechanisms are still poorly understood. Using the Caenorhabditis elegans we discovered that secretory vesicles termed exophers, attributed in neurons to the removal of neurotoxic components, are released by body wall muscles to support embryonic growth. We found that exopher formation (exopheresis) is a non-cell autonomous process regulated by egg formation in the uterus. Our data suggest that exophers serve as transporters for muscle-generated yolk proteins used for nourishing and improving the growth rate of the next generation. We propose that the primary role of muscular exopheresis is to stimulate the reproductive capacity, thereby influencing the adaptation of worm populations to the current environmental conditions.

Competing Interest Statement

The authors have declared no competing interest.

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Posted June 18, 2020.
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Nutritional status and fecundity are synchronised by muscular exopheresis
Michał Turek, Małgorzata Piechota, Nilesh Shanmugam, Marta Niklewicz, Konrad Kowalski, Agnieszka Chacińska, Wojciech Pokrzywa
bioRxiv 2020.06.17.157230; doi: https://doi.org/10.1101/2020.06.17.157230
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Nutritional status and fecundity are synchronised by muscular exopheresis
Michał Turek, Małgorzata Piechota, Nilesh Shanmugam, Marta Niklewicz, Konrad Kowalski, Agnieszka Chacińska, Wojciech Pokrzywa
bioRxiv 2020.06.17.157230; doi: https://doi.org/10.1101/2020.06.17.157230

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