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Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
View ORCID ProfileTyler N. Starr, View ORCID ProfileAllison J. Greaney, View ORCID ProfileSarah K. Hilton, View ORCID ProfileKatharine H.D. Crawford, Mary Jane Navarro, John E. Bowen, View ORCID ProfileM. Alejandra Tortorici, View ORCID ProfileAlexandra C. Walls, View ORCID ProfileDavid Veesler, View ORCID ProfileJesse D. Bloom
doi: https://doi.org/10.1101/2020.06.17.157982
Tyler N. Starr
1Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Allison J. Greaney
1Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
2Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
3Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA
Sarah K. Hilton
1Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
2Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
Katharine H.D. Crawford
1Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
2Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
3Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA
Mary Jane Navarro
4Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
John E. Bowen
4Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
M. Alejandra Tortorici
4Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Alexandra C. Walls
4Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
David Veesler
4Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Jesse D. Bloom
1Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
2Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
5Howard Hughes Medical Institute, Seattle, WA 98109, USA
Article usage
Posted June 17, 2020.
Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
Tyler N. Starr, Allison J. Greaney, Sarah K. Hilton, Katharine H.D. Crawford, Mary Jane Navarro, John E. Bowen, M. Alejandra Tortorici, Alexandra C. Walls, David Veesler, Jesse D. Bloom
bioRxiv 2020.06.17.157982; doi: https://doi.org/10.1101/2020.06.17.157982
Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
Tyler N. Starr, Allison J. Greaney, Sarah K. Hilton, Katharine H.D. Crawford, Mary Jane Navarro, John E. Bowen, M. Alejandra Tortorici, Alexandra C. Walls, David Veesler, Jesse D. Bloom
bioRxiv 2020.06.17.157982; doi: https://doi.org/10.1101/2020.06.17.157982
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