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Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19

Anna E. Oja, Anno Saris, Cherien A. Ghandour, Natasja A.M. Kragten, Boris M. Hogema, Esther J. Nossent, Leo M.A. Heunks, Susan Cuvalay, Ed Slot, Francis H. Swaneveld, Hans Vrielink, Theo Rispens, Ellen van der Schoot, René A.W. van Lier, Anja Ten Brinke, Pleun Hombrink
doi: https://doi.org/10.1101/2020.06.18.159202
Anna E. Oja
1Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
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Anno Saris
2Centre for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam, the Netherlands
3Amsterdam UMC Covid study group, Amsterdam UMC, Amsterdam, the Netherlands
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Cherien A. Ghandour
1Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
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Natasja A.M. Kragten
1Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
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Boris M. Hogema
4Sanquin Diagnostic Services and Sanquin Research, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
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Esther J. Nossent
5Department of Pulmonary Medicine, Amsterdam UMC, Amsterdam, the Netherlands
3Amsterdam UMC Covid study group, Amsterdam UMC, Amsterdam, the Netherlands
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Leo M.A. Heunks
6Department of Intensive Care Medicine, Amsterdam UMC, Amsterdam, the Netherlands
3Amsterdam UMC Covid study group, Amsterdam UMC, Amsterdam, the Netherlands
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Susan Cuvalay
7Unit of Transfusion Medicine, Sanquin Blood Supply, Amsterdam, the Netherlands
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Ed Slot
8Laboratory of Blood-borne Infections, Sanquin Blood Supply, Amsterdam, the Netherlands
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Francis H. Swaneveld
7Unit of Transfusion Medicine, Sanquin Blood Supply, Amsterdam, the Netherlands
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Hans Vrielink
7Unit of Transfusion Medicine, Sanquin Blood Supply, Amsterdam, the Netherlands
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Theo Rispens
9Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
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Ellen van der Schoot
10Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
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René A.W. van Lier
1Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
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Anja Ten Brinke
9Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
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Pleun Hombrink
1Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands
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  • For correspondence: p.hombrink@sanquin.nl
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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic. Understanding both the immunological processes providing specific immunity and potential immunopathology underlying the pathogenesis of this disease may provide valuable insights for potential therapeutic interventions. Here, we quantified SARS-CoV-2 specific immune responses in patients with different clinical courses. Compared to individuals with a mild clinical presentation, CD4+ T cell responses were qualitatively impaired in critically ill patients. Strikingly, however, in these patients the specific IgG antibody response was remarkably strong. The observed disparate T and B cell responses could be indicative of a deregulated immune response in critically ill COVID-19 patients.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 18, 2020.
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Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19
Anna E. Oja, Anno Saris, Cherien A. Ghandour, Natasja A.M. Kragten, Boris M. Hogema, Esther J. Nossent, Leo M.A. Heunks, Susan Cuvalay, Ed Slot, Francis H. Swaneveld, Hans Vrielink, Theo Rispens, Ellen van der Schoot, René A.W. van Lier, Anja Ten Brinke, Pleun Hombrink
bioRxiv 2020.06.18.159202; doi: https://doi.org/10.1101/2020.06.18.159202
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Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19
Anna E. Oja, Anno Saris, Cherien A. Ghandour, Natasja A.M. Kragten, Boris M. Hogema, Esther J. Nossent, Leo M.A. Heunks, Susan Cuvalay, Ed Slot, Francis H. Swaneveld, Hans Vrielink, Theo Rispens, Ellen van der Schoot, René A.W. van Lier, Anja Ten Brinke, Pleun Hombrink
bioRxiv 2020.06.18.159202; doi: https://doi.org/10.1101/2020.06.18.159202

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